| pubmed-article:9490726 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9490726 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9490726 | lifeskim:mentions | umls-concept:C1140618 | lld:lifeskim |
| pubmed-article:9490726 | lifeskim:mentions | umls-concept:C0205102 | lld:lifeskim |
| pubmed-article:9490726 | lifeskim:mentions | umls-concept:C1325779 | lld:lifeskim |
| pubmed-article:9490726 | lifeskim:mentions | umls-concept:C0013352 | lld:lifeskim |
| pubmed-article:9490726 | lifeskim:mentions | umls-concept:C0013126 | lld:lifeskim |
| pubmed-article:9490726 | lifeskim:mentions | umls-concept:C0183683 | lld:lifeskim |
| pubmed-article:9490726 | lifeskim:mentions | umls-concept:C0440043 | lld:lifeskim |
| pubmed-article:9490726 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:9490726 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9490726 | pubmed:dateCreated | 1998-4-16 | lld:pubmed |
| pubmed-article:9490726 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9490726 | pubmed:abstractText | The cytoplasmic dynein light chain Tctex1 is a candidate for one of the distorter products involved in the non-Mendelian transmission of mouse t haplotypes. It has been unclear, however, how the t-specific mutations in this protein, which is found associated with cytoplasmic dynein in many tissues, could result in a male germ cell-specific phenotype. Here, we demonstrate that Tctex1 is not only a cytoplasmic dynein component, but is also present both in mouse sperm and Chlamydomonas flagella. Genetic and biochemical dissection of the Chlamydomonas flagellum reveal that Tctex1 is a previously undescribed component of inner dynein arm I1. Combined with the recent identification of another putative t complex distorter, Tctex2, within the outer dynein arm, these results support the hypothesis that transmission ratio distortion (meiotic drive) of mouse t haplotypes involves dysfunction of both flagellar inner and outer dynein arms but does not require the cytoplasmic isozyme. | lld:pubmed |
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| pubmed-article:9490726 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9490726 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9490726 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9490726 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9490726 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9490726 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9490726 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9490726 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:9490726 | pubmed:author | pubmed-author:HarrisonAA | lld:pubmed |
| pubmed-article:9490726 | pubmed:author | pubmed-author:Olds-ClarkePP | lld:pubmed |
| pubmed-article:9490726 | pubmed:author | pubmed-author:KingS MSM | lld:pubmed |
| pubmed-article:9490726 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9490726 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:9490726 | pubmed:volume | 140 | lld:pubmed |
