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pubmed-article:9485037pubmed:abstractTextGranulocyte colony-stimulating factor receptors (G-CSFRs) have been observed on the surface of not only hematopoietic cells but also several cancer cells. The stimulation of G-CSF has been demonstrated to induce proliferation and activation of G-CSFR-positive cells. In this study, we investigated the expression of G-CSFR on the surface of tumor cells and G-CSF production in oral and mesopharyngeal squamous cell carcinoma (SCC) by an immunohistochemical approach. Of 58 oral and mesopharyngeal SCCs, 31 cases (53.4%) and 36 cases (62.1%) were positive for G-CSFR and G-CSF, respectively. There was no association between G-CSFR expression and G-CSF staining. In the group positive for G-CSFR expression, relapse was significantly more likely after primary treatment (P = 0.0069), whereas there was no association between G-CSFR expression and age, sex, tumor size, lymph node metastasis, and clinical stage. Also, the G-CSFR-positive groups had a significantly lower disease-free and overall survival rate than the G-CSFR-negative groups (P = 0.0172 and 0.0188, respectively). However, none of the clinical markers correlated significantly with G-CSF staining, nor did the status of G-CSF production influence the overall survival. The results imply that assessment of G-CSFR may prove valuable in selecting patients with oral and mesopharyngeal SCC for aggressive therapy.lld:pubmed
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pubmed-article:9485037pubmed:pagination794-800lld:pubmed
pubmed-article:9485037pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9485037pubmed:articleTitleExpression of granulocyte colony-stimulating factor receptor correlates with prognosis in oral and mesopharyngeal carcinoma.lld:pubmed
pubmed-article:9485037pubmed:affiliationDepartment of Otorhinolaryngology, Fukui Medical University, Yoshida-gun, Japan.lld:pubmed
pubmed-article:9485037pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9485037pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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