| pubmed-article:9483450 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9483450 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9483450 | lifeskim:mentions | umls-concept:C0243043 | lld:lifeskim |
| pubmed-article:9483450 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9483450 | lifeskim:mentions | umls-concept:C0876936 | lld:lifeskim |
| pubmed-article:9483450 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9483450 | pubmed:dateCreated | 1998-3-27 | lld:pubmed |
| pubmed-article:9483450 | pubmed:abstractText | A mathematical model of the regulation process of the heat shock protein hsp70 in the cell is presented. The model describes the damaging effect of elevated temperature on proteins; the interaction of free hsp70 with injured proteins and its chaperone role in nascent protein translation; the relation between the amount of free hsp70 and the formation of the activated trimer form of the heat shock factor protein (HSF); the binding of activated HSF with the heat shock elements on the DNA; the transcription of mRNA of hsp70 and the synthesis of hsp70. The reaction of the model to a temporal rise in temperature shows an initial decline and a subsequent sharp rise to an ultimately increased level of free hsp70 in the cell. The response of the model to both a single and two consecutive heat shocks appears to closely resemble experimental data on hsp70 synthesis. This general agreement demonstrates the structure of the model to be sound and suitable as a basis for further modelling the complex tolerance mechanism of the cell. | lld:pubmed |
| pubmed-article:9483450 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9483450 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9483450 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9483450 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9483450 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9483450 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9483450 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9483450 | pubmed:issn | 0265-6736 | lld:pubmed |
| pubmed-article:9483450 | pubmed:author | pubmed-author:van WijkRR | lld:pubmed |
| pubmed-article:9483450 | pubmed:author | pubmed-author:SpaanJ AJA | lld:pubmed |
| pubmed-article:9483450 | pubmed:author | pubmed-author:PeperAA | lld:pubmed |
| pubmed-article:9483450 | pubmed:author | pubmed-author:SourenJ EJE | lld:pubmed |
| pubmed-article:9483450 | pubmed:author | pubmed-author:GrimbergenC... | lld:pubmed |
| pubmed-article:9483450 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9483450 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:9483450 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9483450 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9483450 | pubmed:pagination | 97-124 | lld:pubmed |
| pubmed-article:9483450 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9483450 | pubmed:meshHeading | pubmed-meshheading:9483450-... | lld:pubmed |
| pubmed-article:9483450 | pubmed:meshHeading | pubmed-meshheading:9483450-... | lld:pubmed |
| pubmed-article:9483450 | pubmed:meshHeading | pubmed-meshheading:9483450-... | lld:pubmed |
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| pubmed-article:9483450 | pubmed:meshHeading | pubmed-meshheading:9483450-... | lld:pubmed |
| pubmed-article:9483450 | pubmed:meshHeading | pubmed-meshheading:9483450-... | lld:pubmed |
| pubmed-article:9483450 | pubmed:meshHeading | pubmed-meshheading:9483450-... | lld:pubmed |
| pubmed-article:9483450 | pubmed:meshHeading | pubmed-meshheading:9483450-... | lld:pubmed |
| pubmed-article:9483450 | pubmed:meshHeading | pubmed-meshheading:9483450-... | lld:pubmed |
| pubmed-article:9483450 | pubmed:meshHeading | pubmed-meshheading:9483450-... | lld:pubmed |
| pubmed-article:9483450 | pubmed:meshHeading | pubmed-meshheading:9483450-... | lld:pubmed |
| pubmed-article:9483450 | pubmed:meshHeading | pubmed-meshheading:9483450-... | lld:pubmed |
| pubmed-article:9483450 | pubmed:meshHeading | pubmed-meshheading:9483450-... | lld:pubmed |
| pubmed-article:9483450 | pubmed:articleTitle | A mathematical model of the hsp70 regulation in the cell. | lld:pubmed |
| pubmed-article:9483450 | pubmed:affiliation | Laboratory of Medical Physics, University of Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:9483450 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9483450 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9483450 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9483450 | lld:pubmed |
