| pubmed-article:9482908 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9482908 | lifeskim:mentions | umls-concept:C0029016 | lld:lifeskim |
| pubmed-article:9482908 | lifeskim:mentions | umls-concept:C0018852 | lld:lifeskim |
| pubmed-article:9482908 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
| pubmed-article:9482908 | lifeskim:mentions | umls-concept:C2745955 | lld:lifeskim |
| pubmed-article:9482908 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:9482908 | lifeskim:mentions | umls-concept:C0332597 | lld:lifeskim |
| pubmed-article:9482908 | lifeskim:mentions | umls-concept:C0332183 | lld:lifeskim |
| pubmed-article:9482908 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9482908 | pubmed:dateCreated | 1998-4-9 | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:abstractText | Human naive and germinal center (GC) B cells were sorted by flow cytometry and rearranged VH region genes were amplified and sequenced from single cells. Whereas no deletions or insertions were found in naive B cells, approximately 4% of in-frame and >40% of out-of-frame rearrangements of GC B cells harbored deletions and/or insertions of variable length. The pattern of deletions/insertions and their restriction to mutated V genes strongly suggests that they result from somatic hypermutation. Deletions and insertions account for approximately 6% of somatic mutations introduced into rearranged VH region genes of GC B cells. These deletions/insertions seem to be the main cause for the generation of heavy chain disease proteins. Furthermore, it appears that several types of oncogene translocations (like c-myc translocations in Burkitt's lymphoma) occur as a byproduct of somatic hypermutation within the GC-and not during V(D)J recombination in the bone marrow as previously thought. | lld:pubmed |
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| pubmed-article:9482908 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9482908 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9482908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482908 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9482908 | pubmed:month | Mar | lld:pubmed |
