| pubmed-article:9482868 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9482868 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:9482868 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9482868 | pubmed:dateCreated | 1998-4-9 | lld:pubmed |
| pubmed-article:9482868 | pubmed:abstractText | A DNA structure is described that can cleave single-stranded DNA oligonucleotides in the presence of ionic copper. This "deoxyribozyme" can self-cleave or can operate as a bimolecular complex that simultaneously makes use of duplex and triplex interactions to bind and cleave separate DNA substrates. Bimolecular deoxyribozyme-mediated strand scission proceeds with a kobs of 0.2 min-1, whereas the corresponding uncatalyzed reaction could not be detected. The duplex and triplex recognition domains can be altered, making possible the targeted cleavage of single-stranded DNAs with different nucleotide sequences. Several small synthetic DNAs were made to function as simple "restriction enzymes" for the site-specific cleavage of single-stranded DNA. | lld:pubmed |
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| pubmed-article:9482868 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9482868 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9482868 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9482868 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9482868 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9482868 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9482868 | pubmed:author | pubmed-author:BreakerR RRR | lld:pubmed |
| pubmed-article:9482868 | pubmed:author | pubmed-author:CarmiNN | lld:pubmed |
| pubmed-article:9482868 | pubmed:author | pubmed-author:BalkhiS RSR | lld:pubmed |
| pubmed-article:9482868 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9482868 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:9482868 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:9482868 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9482868 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9482868 | pubmed:pagination | 2233-7 | lld:pubmed |
| pubmed-article:9482868 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
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| pubmed-article:9482868 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9482868 | pubmed:articleTitle | Cleaving DNA with DNA. | lld:pubmed |
| pubmed-article:9482868 | pubmed:affiliation | Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520-8103, USA. | lld:pubmed |
| pubmed-article:9482868 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9482868 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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