| pubmed-article:9480990 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9480990 | lifeskim:mentions | umls-concept:C0376526 | lld:lifeskim |
| pubmed-article:9480990 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:9480990 | lifeskim:mentions | umls-concept:C1512977 | lld:lifeskim |
| pubmed-article:9480990 | lifeskim:mentions | umls-concept:C0682972 | lld:lifeskim |
| pubmed-article:9480990 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:9480990 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:9480990 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:9480990 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:9480990 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9480990 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9480990 | pubmed:dateCreated | 1998-3-24 | lld:pubmed |
| pubmed-article:9480990 | pubmed:abstractText | Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8, which is consistently present in tissues of patients with Kaposi's sarcoma and primary effusion lymphomas, contains a gene that encodes a G protein-coupled receptor (KSHV-GPCR). We recently showed that KSHV-GPCR exhibits constitutive signaling via activation of phosphoinositide-specific phospholipase C and stimulates cell proliferation and transformation. In this study, we determined whether normal cellular mechanisms could inhibit constitutive signaling by KSHV-GPCR and thereby KSHV-GPCR-stimulated proliferation. We show that coexpression of GPCR-specific kinases (GRKs) and activation of protein kinase C inhibit constitutive signaling by KSHV-GPCR in COS-1 monkey kidney cells and in mouse NIH 3T3 cells. Moreover, GRK-5 but not GRK-2 inhibits KSHV-GPCR-stimulated proliferation of rodent fibroblasts. These data provide evidence that cell regulatory pathways of receptor desensitization may be therapeutic targets in human diseases involving constitutively active receptors. | lld:pubmed |
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| pubmed-article:9480990 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9480990 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480990 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9480990 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9480990 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9480990 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9480990 | pubmed:author | pubmed-author:GershengornM... | lld:pubmed |
| pubmed-article:9480990 | pubmed:author | pubmed-author:BainNN | lld:pubmed |
| pubmed-article:9480990 | pubmed:author | pubmed-author:CesarmanEE | lld:pubmed |
| pubmed-article:9480990 | pubmed:author | pubmed-author:Geras-RaakaEE | lld:pubmed |
| pubmed-article:9480990 | pubmed:author | pubmed-author:MesriE AEA | lld:pubmed |
| pubmed-article:9480990 | pubmed:author | pubmed-author:ArvanitakisLL | lld:pubmed |
| pubmed-article:9480990 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9480990 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:9480990 | pubmed:volume | 187 | lld:pubmed |
| pubmed-article:9480990 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9480990 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9480990 | pubmed:pagination | 801-6 | lld:pubmed |
| pubmed-article:9480990 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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