| pubmed-article:9480923 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9480923 | lifeskim:mentions | umls-concept:C0087140 | lld:lifeskim |
| pubmed-article:9480923 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:9480923 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:9480923 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:9480923 | lifeskim:mentions | umls-concept:C0969709 | lld:lifeskim |
| pubmed-article:9480923 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:9480923 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9480923 | lifeskim:mentions | umls-concept:C0205228 | lld:lifeskim |
| pubmed-article:9480923 | lifeskim:mentions | umls-concept:C0083632 | lld:lifeskim |
| pubmed-article:9480923 | pubmed:dateCreated | 1998-4-16 | lld:pubmed |
| pubmed-article:9480923 | pubmed:abstractText | Ceramide is an important regulatory molecule implicated in a variety of biological processes in response to stress and cytokines. To understand the signal transduction pathway of ceramide to the nucleus, in the present study, we examined whether C2-ceramide, a cell permeable ceramide, activates c-fos serum response element (SRE). Treatment of Rat-2 fibroblast cells with C2-ceramide caused the stimulation of c-fos SRE-dependent reporter gene activity in a dose- and time-dependent manner by transient transfection analysis. Next, we examined the role of Rho family GTPases in the ceramide-induced signalling to SRE activation. By reporter gene analysis following transient transfections with various plasmids expressing a dominant negative mutant form of Cdc42, Rac1 or RhoA, C2-ceramide-induced SRE activation was shown to be selectively repressed by pEXV-RacN17 encoding a dominant negative mutant of Rac1, suggesting that Rac activity is essential for the signalling cascade of ceramide to the nucleus. In a further study to analyse the downstream mediator of Rac in the ceramide-signalling pathway, we observed that either pretreatment with mepacrine, a potent and specific inhibitor of phospholipase A2, or co-transfection with antisense cytosolic phospholipase A2 (cPLA2) oligonucleotide repressed the C2-ceramide-induced SRE activation selectively, implying a critical role of cPLA2 in C2-ceramide-induced signalling to nucleus. Consistent with these results, the translocation of cPLA2 protein as well as the release of arachidonic acid, a principal product of phospholipase A2, was rapidly induced by the addition of C2-ceramide in a Rac-dependent manner. Together, our findings suggest the critical role of 'Rac and subsequent activation of phospholipase A2' in ceramide-signalling to nucleus. | lld:pubmed |
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| pubmed-article:9480923 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9480923 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9480923 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9480923 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9480923 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:9480923 | pubmed:author | pubmed-author:KimJ HJH | lld:pubmed |
| pubmed-article:9480923 | pubmed:author | pubmed-author:KimB CBC | lld:pubmed |
| pubmed-article:9480923 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9480923 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9480923 | pubmed:volume | 330 ( Pt 2) | lld:pubmed |
| pubmed-article:9480923 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9480923 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9480923 | pubmed:pagination | 1009-14 | lld:pubmed |
| pubmed-article:9480923 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9480923 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9480923 | pubmed:articleTitle | Exogenous C2-ceramide activates c-fos serum response element via Rac-dependent signalling pathway. | lld:pubmed |
| pubmed-article:9480923 | pubmed:affiliation | Laboratory of Molecular & Cellular Genetics, Institute of Environment and Life Science, Hallym University, Chun-Cheon, Kangwon-do, South Korea #200-702. | lld:pubmed |
| pubmed-article:9480923 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9480923 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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