| pubmed-article:9480864 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9480864 | lifeskim:mentions | umls-concept:C0682972 | lld:lifeskim |
| pubmed-article:9480864 | lifeskim:mentions | umls-concept:C1414253 | lld:lifeskim |
| pubmed-article:9480864 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:9480864 | lifeskim:mentions | umls-concept:C0074992 | lld:lifeskim |
| pubmed-article:9480864 | pubmed:dateCreated | 1998-4-16 | lld:pubmed |
| pubmed-article:9480864 | pubmed:abstractText | Sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) are structurally related lipid mediators that act on distinct G-protein-coupled receptors to evoke similar responses, including Ca2+ mobilization, adenylate cyclase inhibition, and mitogen-activated protein (MAP) kinase activation. However, little is still known about the respective receptors. A recently cloned putative LPA receptor (Vzg-1/Edg-2) is similar to an orphan Gi-coupled receptor termed Edg-1. Here we show that expression of Edg-1 in Sf9 and COS-7 cells results in inhibition of adenylate cyclase and activation of MAP kinase (Gi-mediated), but not Ca2+ mobilization, in response to S1P. These responses are specific in that (i) S1P action is not mimicked by LPA, and (ii) Vzg-1/Edg-2 cannot substitute for Edg-1. Thus the Edg-1 receptor is capable of mediating a subset of the cellular responses to S1P. | lld:pubmed |
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| pubmed-article:9480864 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9480864 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480864 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9480864 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9480864 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9480864 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:9480864 | pubmed:author | pubmed-author:MoolenaarW... | lld:pubmed |
| pubmed-article:9480864 | pubmed:author | pubmed-author:VerlaanII | lld:pubmed |
| pubmed-article:9480864 | pubmed:author | pubmed-author:PostmaF RFR | lld:pubmed |
| pubmed-article:9480864 | pubmed:author | pubmed-author:ZondagG CGC | lld:pubmed |
| pubmed-article:9480864 | pubmed:author | pubmed-author:EttenI VIV | lld:pubmed |
| pubmed-article:9480864 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9480864 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9480864 | pubmed:volume | 330 ( Pt 2) | lld:pubmed |
| pubmed-article:9480864 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9480864 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9480864 | pubmed:pagination | 605-9 | lld:pubmed |
| pubmed-article:9480864 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9480864 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9480864 | pubmed:articleTitle | Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1. | lld:pubmed |
| pubmed-article:9480864 | pubmed:affiliation | Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:9480864 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9480864 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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