| pubmed-article:9480644 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9480644 | lifeskim:mentions | umls-concept:C0995660 | lld:lifeskim |
| pubmed-article:9480644 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:9480644 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:9480644 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:9480644 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:9480644 | pubmed:dateCreated | 1998-2-25 | lld:pubmed |
| pubmed-article:9480644 | pubmed:abstractText | Renibacterium salmoninarum, the agent of bacterial kidney disease in salmonids, releases high concentrations of extracellular protein in tissues of infected fish. The extracellular protein consists almost entirely of a 57-kDa protein and derivatives of degradation and aggregation of the same molecule. The 57-kDa protein and its derivatives were fractionated into defined ranges of molecular mass. Separated fractions continued to produce degradation and aggregation products. One-dimensional electrophoretic separation of extracellular protein revealed a number of proteolytically active bands from > 100 to approximately 18 kDa associated with various 57-kDa protein derivatives in the different molecular mass fractions. Two-dimensional separation of extracellular protein showed that continued degradation and aggregation, similar both in location and behavior to some of the 57-kDa protein derivatives, was also displayed by the proteolytically active bands after their separation. Effects of reducing agents and sulfhydryl group proteinase inhibitors indicated a common mechanism for the proteolytically active polypeptides characteristic of a thiol proteinase. The results suggested that the 57-kDa protein and some of its derivatives undergo autolytic cleavage, releasing a proteolytically active polypeptide(s) of at least 18 kDa. Soluble polysaccharide-like material also was detected in extracellular products and tissue from infected fish. Antiserum to the polysaccharide-like material cross-reacted with O-polysaccharide of the fish pathogen Aeromonas salmonicida, suggesting some structural similarity between these polysaccharides. The polysaccharide and the proteolytic activity associated with the 57-kDa protein derivatives should be investigated with respect to the pathogenesis of R. salmoninarum infections. | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9480644 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9480644 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9480644 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9480644 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9480644 | pubmed:issn | 0099-2240 | lld:pubmed |
| pubmed-article:9480644 | pubmed:author | pubmed-author:LynchW HWH | lld:pubmed |
| pubmed-article:9480644 | pubmed:author | pubmed-author:GriffithsS... | lld:pubmed |
| pubmed-article:9480644 | pubmed:author | pubmed-author:BarskyS HSH | lld:pubmed |
| pubmed-article:9480644 | pubmed:author | pubmed-author:BannisterL... | lld:pubmed |
| pubmed-article:9480644 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9480644 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:9480644 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9480644 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9480644 | pubmed:pagination | 3770-5 | lld:pubmed |
| pubmed-article:9480644 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:meshHeading | pubmed-meshheading:9480644-... | lld:pubmed |
| pubmed-article:9480644 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9480644 | pubmed:articleTitle | Further characterization of Renibacterium salmoninarum extracellular products. | lld:pubmed |
| pubmed-article:9480644 | pubmed:affiliation | Department of Biology, University of New Brunswick, Fredericton, Canada. | lld:pubmed |
| pubmed-article:9480644 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9480644 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9480644 | lld:pubmed |
