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pubmed-article:9480093pubmed:abstractTextThe influence of platelet-specific and HLA antibodies on primary hemostasis was investigated by the in vitro bleeding test (IVBT). Seven of 12 plasmas with HPA-1a (PLA1) antibodies and two with antibodies against glycoprotein Ib/IX significantly inhibited the IVBT of normal cross-match-positive donor blood. This correlated with an increase of GMP-140 on the platelets determined by flow cytometry. Therefore the inhibition of the IVBT was interpreted to be due to rapid platelet activation by platelet-specific antibodies followed by an irreversible loss of function. In contrast, with HLA antibodies neither activation nor inhibition of the platelet function could be proven.lld:pubmed
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pubmed-article:9480093pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9480093pubmed:articleTitle[Effect of HPA-1a(PLA1) and HLA antibodies on platelet function, measured with the in vitro bleeding test].lld:pubmed
pubmed-article:9480093pubmed:affiliationAbteilung für Transfusionsmedizin und Gerinnungsphysiologie, Universitätsklinikum, Marburg.lld:pubmed
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pubmed-article:9480093pubmed:publicationTypeEnglish Abstractlld:pubmed