| pubmed-article:9478972 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9478972 | lifeskim:mentions | umls-concept:C0035679 | lld:lifeskim |
| pubmed-article:9478972 | lifeskim:mentions | umls-concept:C0012899 | lld:lifeskim |
| pubmed-article:9478972 | lifeskim:mentions | umls-concept:C1519751 | lld:lifeskim |
| pubmed-article:9478972 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:9478972 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:9478972 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:9478972 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:9478972 | pubmed:dateCreated | 1998-3-25 | lld:pubmed |
| pubmed-article:9478972 | pubmed:abstractText | We have shown previously that UV radiation and other DNA-damaging agents induce the ubiquitination of a portion of the RNA polymerase II large subunit (Pol II LS). In the present study UV irradiation of repair-competent fibroblasts induced a transient reduction of the Pol II LS level; new protein synthesis restored Pol II LS to the base-line level within 16-24 h. In repair-deficient xeroderma pigmentosum cells, UV radiation-induced ubiquitination of Pol II LS was followed by a sustained reduction of Pol II LS level. In both normal and xeroderma pigmentosum cells, the ubiquitinated Pol II LS had a hyperphosphorylated COOH-terminal domain (CTD), which is characteristic of elongating Pol II. The portion of Pol II LS whose steady-state level diminished most quickly had a relatively hypophosphorylated CTD. The ubiquitinated residues did not map to the CTD. Importantly, UV-induced reduction of Pol II LS level in repair-competent or -deficient cells was inhibited by the proteasome inhibitors lactacystin or MG132. These data demonstrate that UV-induced ubiquitination of Pol II LS is followed by its degradation in the proteasome. These results suggest, contrary to a current model of transcription-coupled DNA repair, that elongating Pol II complexes which arrest at intragenic DNA lesions may be aborted rather than resuming elongation after repair takes place. | lld:pubmed |
| pubmed-article:9478972 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9478972 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9478972 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9478972 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9478972 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9478972 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9478972 | pubmed:author | pubmed-author:WarrenS LSL | lld:pubmed |
| pubmed-article:9478972 | pubmed:author | pubmed-author:CordenJJ | lld:pubmed |
| pubmed-article:9478972 | pubmed:author | pubmed-author:Balasubramani... | lld:pubmed |
| pubmed-article:9478972 | pubmed:author | pubmed-author:BregmanD BDB | lld:pubmed |
| pubmed-article:9478972 | pubmed:author | pubmed-author:RatnerJ NJN | lld:pubmed |
| pubmed-article:9478972 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9478972 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:9478972 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9478972 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9478972 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9478972 | pubmed:pagination | 5184-9 | lld:pubmed |
| pubmed-article:9478972 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9478972 | pubmed:meshHeading | pubmed-meshheading:9478972-... | lld:pubmed |
| pubmed-article:9478972 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9478972 | pubmed:articleTitle | Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. Implications for transcription-coupled DNA repair. | lld:pubmed |
| pubmed-article:9478972 | pubmed:affiliation | Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA. | lld:pubmed |
| pubmed-article:9478972 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9478972 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9478972 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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