| pubmed-article:9465090 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9465090 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:9465090 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9465090 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9465090 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:9465090 | lifeskim:mentions | umls-concept:C0164198 | lld:lifeskim |
| pubmed-article:9465090 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:9465090 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9465090 | pubmed:dateCreated | 1998-3-19 | lld:pubmed |
| pubmed-article:9465090 | pubmed:abstractText | Cyclophilins are a family of proteins that bind cyclosporin A (CsA) and possess peptidyl-prolyl cis-trans isomerase activity. In addition, they are secreted by activated cells and act in a cytokine-like manner, presumably via signaling through a cell surface cyclophilin receptor. More recently, host-derived cyclophilin A (CyPA) has been shown to be incorporated into HIV-1 virions and its incorporation essential for viral infectivity. Here we present evidence supporting a role for viral-associated CyPA in the early events of HIV-1 infection. We report that HIV-1 infection of primary peripheral blood mononuclear cells can be inhibited by: (i) an excess of exogenously added CyPA; (ii) a CsA analogue unable to enter the cells; (iii) neutralizing antibodies to CyPA. Taken together with our observations that recombinant CyPA-induced mobilization of calcium in immortalized, as well as primary, CD4+ T lymphocytes, and that incubation of T cells with iodinated CyPA, followed by chemical cross-linking, resulted in the formation of a high molecular mass complex on the cell surface, these results suggest that HIV-1-associated CyPA mediates an early event in viral infection via interaction with a cellular receptor. This interaction may present a target for anti-HIV therapies and vaccines. | lld:pubmed |
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| pubmed-article:9465090 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9465090 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9465090 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9465090 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9465090 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9465090 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9465090 | pubmed:author | pubmed-author:MitchellRR | lld:pubmed |
| pubmed-article:9465090 | pubmed:author | pubmed-author:CeramiAA | lld:pubmed |
| pubmed-article:9465090 | pubmed:author | pubmed-author:UlrichPP | lld:pubmed |
| pubmed-article:9465090 | pubmed:author | pubmed-author:SherryBB | lld:pubmed |
| pubmed-article:9465090 | pubmed:author | pubmed-author:RiceAA | lld:pubmed |
| pubmed-article:9465090 | pubmed:author | pubmed-author:BucalaRR | lld:pubmed |
| pubmed-article:9465090 | pubmed:author | pubmed-author:AlfanoMM | lld:pubmed |
| pubmed-article:9465090 | pubmed:author | pubmed-author:BukrinskyMM | lld:pubmed |
| pubmed-article:9465090 | pubmed:author | pubmed-author:ZybarthGG | lld:pubmed |
| pubmed-article:9465090 | pubmed:author | pubmed-author:DubrovskyLL | lld:pubmed |
| pubmed-article:9465090 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9465090 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:9465090 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:9465090 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9465090 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9465090 | pubmed:pagination | 1758-63 | lld:pubmed |
| pubmed-article:9465090 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9465090 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9465090 | pubmed:articleTitle | Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes. | lld:pubmed |
| pubmed-article:9465090 | pubmed:affiliation | The Picower Institute for Medical Research, Manhasset, NY 11030, USA. | lld:pubmed |
| pubmed-article:9465090 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9465090 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9465090 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:268373 | entrezgene:pubmed | pubmed-article:9465090 | lld:entrezgene |
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