pubmed-article:9464271 | rdf:type | pubmed:Citation | lld:pubmed |
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pubmed-article:9464271 | lifeskim:mentions | umls-concept:C0009015 | lld:lifeskim |
pubmed-article:9464271 | lifeskim:mentions | umls-concept:C0019643 | lld:lifeskim |
pubmed-article:9464271 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
pubmed-article:9464271 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
pubmed-article:9464271 | lifeskim:mentions | umls-concept:C0887824 | lld:lifeskim |
pubmed-article:9464271 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
pubmed-article:9464271 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
pubmed-article:9464271 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:9464271 | pubmed:dateCreated | 1998-3-6 | lld:pubmed |
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pubmed-article:9464271 | pubmed:abstractText | The nucleosomal histones can be modified through reversible acetylation by histone acetyltransferases (HATs) and deacetylases (HDACs). HATs induce nucleosomal relaxation and allow DNA-binding by transcriptional activators. HDACs from corepressor complexes which negatively regulate cell growth. However, the HDAC inhibitors butyrate and Trichostatin A block T cell proliferation, suggesting that not all effects of HDACs lead to repression. Using mRNA differential display and 5'RACE we isolated human HDAC3, a novel gene that is upregulated in PHA-activated T cell clones. HDAC3 is homologous to other human HDACs and yeast RPD3. In peripheral blood mononuclear cells (PBMCs), activation by PHA, PMA and alpha-CD3 increased HDAC mRNA but no effect was seen with IFN-gamma, LPS, or IL-4. In contrast, GMCSF downregulated PBMC levels of HDAC3 mRNA. All HDACs were found to be ubiquitously expressed in immune and non-immune tissues. In human myeloid leukemia THP-1 cells, HDAC3 transfection resulted in increased size, aberrant nuclear morphology and cell cycle G2/M cell accumulation. Functional activity of the expressed HDAC3 protein was confirmed in alpha-HDAC3 antibody immunoprecipitates by a histone deacetylase assay. Our study suggests the participation of HDACs in cell cycle progression and activation. | lld:pubmed |
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pubmed-article:9464271 | pubmed:language | eng | lld:pubmed |
pubmed-article:9464271 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9464271 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:9464271 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9464271 | pubmed:month | Jan | lld:pubmed |
pubmed-article:9464271 | pubmed:issn | 0006-291X | lld:pubmed |
pubmed-article:9464271 | pubmed:author | pubmed-author:KojimaRR | lld:pubmed |
pubmed-article:9464271 | pubmed:author | pubmed-author:RandallJJ | lld:pubmed |
pubmed-article:9464271 | pubmed:author | pubmed-author:HaflerD ADA | lld:pubmed |
pubmed-article:9464271 | pubmed:author | pubmed-author:DangondFF | lld:pubmed |
pubmed-article:9464271 | pubmed:author | pubmed-author:GullansS RSR | lld:pubmed |
pubmed-article:9464271 | pubmed:author | pubmed-author:UtkuNN | lld:pubmed |
pubmed-article:9464271 | pubmed:author | pubmed-author:TongJ KJK | lld:pubmed |
pubmed-article:9464271 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9464271 | pubmed:day | 26 | lld:pubmed |
pubmed-article:9464271 | pubmed:volume | 242 | lld:pubmed |
pubmed-article:9464271 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9464271 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9464271 | pubmed:pagination | 648-52 | lld:pubmed |
pubmed-article:9464271 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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pubmed-article:9464271 | pubmed:year | 1998 | lld:pubmed |
pubmed-article:9464271 | pubmed:articleTitle | Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells. | lld:pubmed |
pubmed-article:9464271 | pubmed:affiliation | Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. dangond@cnd.bwh.harvard.edu | lld:pubmed |
pubmed-article:9464271 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9464271 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:9464271 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
pubmed-article:9464271 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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