| pubmed-article:9463410 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9463410 | lifeskim:mentions | umls-concept:C0000768 | lld:lifeskim |
| pubmed-article:9463410 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9463410 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:9463410 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:9463410 | lifeskim:mentions | umls-concept:C0282566 | lld:lifeskim |
| pubmed-article:9463410 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:9463410 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9463410 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9463410 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9463410 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9463410 | pubmed:dateCreated | 1998-3-23 | lld:pubmed |
| pubmed-article:9463410 | pubmed:abstractText | Monocyte chemoattractant protein 1 (MCP-1) is a CC chemokine that attracts monocytes, memory T lymphocytes, and natural killer cells. Because other chemokines have similar target cell specificities and because CCR2, a cloned MCP-1 receptor, binds other ligands, it has been uncertain whether MCP-1 plays a unique role in recruiting mononuclear cells in vivo. To address this question, we disrupted SCYA2 (the gene encoding MCP-1) and tested MCP-1-deficient mice in models of inflammation. Despite normal numbers of circulating leukocytes and resident macrophages, MCP-1(-/-) mice were specifically unable to recruit monocytes 72 h after intraperitoneal thioglycollate administration. Similarly, accumulation of F4/80+ monocytes in delayed-type hypersensitivity lesions was impaired, although the swelling response was normal. Development of secondary pulmonary granulomata in response to Schistosoma mansoni eggs was blunted in MCP-1(-/-) mice, as was expression of IL-4, IL-5, and interferon gamma in splenocytes. In contrast, MCP-1(-/-) mice were indistinguishable from wild-type mice in their ability to clear Mycobacterium tuberculosis. Our data indicate that MCP-1 is uniquely essential for monocyte recruitment in several inflammatory models in vivo and influences expression of cytokines related to T helper responses. | lld:pubmed |
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| pubmed-article:9463410 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9463410 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9463410 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9463410 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9463410 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9463410 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9463410 | pubmed:author | pubmed-author:KunkelS LSL | lld:pubmed |
| pubmed-article:9463410 | pubmed:author | pubmed-author:LoHH | lld:pubmed |
| pubmed-article:9463410 | pubmed:author | pubmed-author:RollinsB JBJ | lld:pubmed |
| pubmed-article:9463410 | pubmed:author | pubmed-author:GerardCC | lld:pubmed |
| pubmed-article:9463410 | pubmed:author | pubmed-author:RutledgeB JBJ | lld:pubmed |
| pubmed-article:9463410 | pubmed:author | pubmed-author:JL | lld:pubmed |
| pubmed-article:9463410 | pubmed:author | pubmed-author:LukacsN WNW | lld:pubmed |
| pubmed-article:9463410 | pubmed:author | pubmed-author:FiorilloJJ | lld:pubmed |
| pubmed-article:9463410 | pubmed:author | pubmed-author:NorthRR | lld:pubmed |
| pubmed-article:9463410 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9463410 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:9463410 | pubmed:volume | 187 | lld:pubmed |
| pubmed-article:9463410 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9463410 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9463410 | pubmed:pagination | 601-8 | lld:pubmed |
| pubmed-article:9463410 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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