| pubmed-article:9458851 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9458851 | lifeskim:mentions | umls-concept:C0026844 | lld:lifeskim |
| pubmed-article:9458851 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:9458851 | lifeskim:mentions | umls-concept:C0225828 | lld:lifeskim |
| pubmed-article:9458851 | lifeskim:mentions | umls-concept:C0032578 | lld:lifeskim |
| pubmed-article:9458851 | lifeskim:mentions | umls-concept:C0020564 | lld:lifeskim |
| pubmed-article:9458851 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:9458851 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:9458851 | lifeskim:mentions | umls-concept:C1518425 | lld:lifeskim |
| pubmed-article:9458851 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9458851 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:9458851 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:9458851 | pubmed:issue | 1 Pt 2 | lld:pubmed |
| pubmed-article:9458851 | pubmed:dateCreated | 1998-2-23 | lld:pubmed |
| pubmed-article:9458851 | pubmed:abstractText | To assess the vascular and cardiac response to NO (nitric oxide) synthase (NOS) blockade in vivo, Wistar-Kyoto rats (WKY) were treated for 3 wk with NG-nitro-L-arginine methyl ester (L-NAME; 10 mg.kg-1.day-1). L-NAME treatment induced hypertension that was associated with increased plasma renin activity. Flow cytometry cell cycle DNA analysis showed that aortic vascular smooth muscle cells (VSMC) from L-NAME-treated WKY had a significantly higher polyploid population compared with WKY controls. Using organ bath experiments, we have shown that aortic rings from L-NAME-treated WKY have an increased contractile response to phenylephrine and impaired relaxation to carbachol compared with control rings. NOS blockade in vivo caused a significant increase in cardiac and left ventricular hypertrophy. Northern mRNA analysis of the myocardium showed that L-NAME treatment caused reexpression of the fetal skeletal alpha-actin isoform without alterations in collagen type I expression, a pattern indicating true hypertrophy of the cardiomyocytes. These studies provide further insight to confirm that NO deficiency in vivo results in the development of vascular and cardiac hypertrophy. | lld:pubmed |
| pubmed-article:9458851 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9458851 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9458851 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9458851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9458851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9458851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9458851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9458851 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9458851 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9458851 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9458851 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:9458851 | pubmed:author | pubmed-author:ReidJ LJL | lld:pubmed |
| pubmed-article:9458851 | pubmed:author | pubmed-author:MortonJ JJJ | lld:pubmed |
| pubmed-article:9458851 | pubmed:author | pubmed-author:HamiltonC ACA | lld:pubmed |
| pubmed-article:9458851 | pubmed:author | pubmed-author:GrahamDD | lld:pubmed |
| pubmed-article:9458851 | pubmed:author | pubmed-author:McIntyreMM | lld:pubmed |
| pubmed-article:9458851 | pubmed:author | pubmed-author:DevlinA MAM | lld:pubmed |
| pubmed-article:9458851 | pubmed:author | pubmed-author:McPhadenA RAR | lld:pubmed |
| pubmed-article:9458851 | pubmed:author | pubmed-author:DominiczakA... | lld:pubmed |
| pubmed-article:9458851 | pubmed:author | pubmed-author:BrosnanM JMJ | lld:pubmed |
| pubmed-article:9458851 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9458851 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:9458851 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9458851 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9458851 | pubmed:pagination | H52-9 | lld:pubmed |
| pubmed-article:9458851 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9458851 | pubmed:meshHeading | pubmed-meshheading:9458851-... | lld:pubmed |
| pubmed-article:9458851 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9458851 | pubmed:articleTitle | Vascular smooth muscle cell polyploidy and cardiomyocyte hypertrophy due to chronic NOS inhibition in vivo. | lld:pubmed |
| pubmed-article:9458851 | pubmed:affiliation | Department of Medicine and Therapeutics, University of Glasgow, Western Infirmary, United Kingdom. | lld:pubmed |
| pubmed-article:9458851 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9458851 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:9458851 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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