Linked Life Data

9456308

Source:http://linkedlifedata.com/resource/pubmed/id/9456308

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pubmed-article:9456308pubmed:dateCreated1998-3-20lld:pubmed
pubmed-article:9456308pubmed:abstractTextThe mutual inhibition between quinine and etoposide with their major metabolic pathways (i.e. quinine 3-hydroxylation and etoposide 3'-demethylation) was examined in vitro by human liver microsomes. Etoposide inhibited quinine 3-hydroxylation in a concentration-dependent manner with a mean IC50 of 65 microM. The mean maximum inhibition by etoposide (100 micro) of quinine 3-hydroxylation was about 60%. Similarly, etoposide 3'-demethylation was inhibited by quinine in a concentration-related manner with a mean IC50 value of 90 microM. The mean maximum inhibition by quinine (100 M) of etoposide 3'-demethylation was about 52%. An excellent correlation (r = 0.947, p < 0.01) between quinine 3-hydroxylase and etoposide 3'-demethylase activities in six different human liver microsomes was observed. Two inhibitors of CYP3A4, ketoconazole (1 microM) and troleandomycin (100 microM), inhibited quinine 3-hydroxylation by about 90% and 80%, and etoposide 3'-demethylation by about 75% and 65%, respectively. We conclude that quinine and etoposide mutually inhibit the metabolism of each other, consistent with the previous finding that CYP3A4 catalyzes the metabolism of both substrates.lld:pubmed
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pubmed-article:9456308pubmed:authorpubmed-author:KawashiroTTlld:pubmed
pubmed-article:9456308pubmed:authorpubmed-author:IshizakiTTlld:pubmed
pubmed-article:9456308pubmed:authorpubmed-author:ZhaoX JXJlld:pubmed
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pubmed-article:9456308pubmed:volume26lld:pubmed
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pubmed-article:9456308pubmed:pagination188-91lld:pubmed
pubmed-article:9456308pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:9456308pubmed:year1998lld:pubmed
pubmed-article:9456308pubmed:articleTitleMutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.lld:pubmed
pubmed-article:9456308pubmed:affiliationDepartment of Clinical Pharmacology, Research Institute, International Medical Center of Japan, Tokyo, Japan.lld:pubmed
pubmed-article:9456308pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9456308pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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