| pubmed-article:9454770 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9454770 | lifeskim:mentions | umls-concept:C0679729 | lld:lifeskim |
| pubmed-article:9454770 | lifeskim:mentions | umls-concept:C1512162 | lld:lifeskim |
| pubmed-article:9454770 | lifeskim:mentions | umls-concept:C1519429 | lld:lifeskim |
| pubmed-article:9454770 | lifeskim:mentions | umls-concept:C0681827 | lld:lifeskim |
| pubmed-article:9454770 | lifeskim:mentions | umls-concept:C0024305 | lld:lifeskim |
| pubmed-article:9454770 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9454770 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:9454770 | lifeskim:mentions | umls-concept:C0441994 | lld:lifeskim |
| pubmed-article:9454770 | lifeskim:mentions | umls-concept:C0334094 | lld:lifeskim |
| pubmed-article:9454770 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9454770 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9454770 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9454770 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9454770 | pubmed:dateCreated | 1998-3-3 | lld:pubmed |
| pubmed-article:9454770 | pubmed:abstractText | An inverse relationship between BCL-2 expression and cell cycle transition has been suggested by recent studies in murine models. To investigate the clinical relevance of these laboratory studies, a group of 116 paraffin-embedded non-Hodgkin's lymphoma (NHL) biopsy specimens (Working Formulation Groups D-H, and J) from a cooperative group study of cellular DNA content were analyzed for the 14;18 translocation using polymerase chain reaction (PCR)-based methods and, if sufficient tissue remained, for BCL-2 and BAX expression by immunohistochemistry. The results of these studies were then compared with the results of the previously performed flow cytometric analysis of ploidy and proliferative activity (S-phase-fraction). BCL-2 expression was inversely associated with proliferative activity (P = .001; n = 41), but there was no association between staining for Bax and %S-phase. Ploidy was not associated with either BCL-2 or BAX expression. The t(14;18) was detected in 21 of the 54 cases in which PCR-amplifiable DNA was recovered; 20 of these occurred at the major breakpoint region and 1 at the minor breakpoint region. High levels of BCL-2 or BAX expression occurred independently of t(14;18). There was no association between t(14;18) and either ploidy or proliferative activity. The inverse relationship between BCL-2 expression and proliferative activity in the intermediate- and high-grade NHLs is consistent with recent studies suggesting that Bcl-2 both retards entry into the cell cycle and inhibits apoptosis. | lld:pubmed |
| pubmed-article:9454770 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9454770 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9454770 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9454770 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9454770 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9454770 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9454770 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9454770 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9454770 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9454770 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:9454770 | pubmed:author | pubmed-author:ReedJ CJC | lld:pubmed |
| pubmed-article:9454770 | pubmed:author | pubmed-author:FisherR IRI | lld:pubmed |
| pubmed-article:9454770 | pubmed:author | pubmed-author:OkenM MMM | lld:pubmed |
| pubmed-article:9454770 | pubmed:author | pubmed-author:KrajewskiSS | lld:pubmed |
| pubmed-article:9454770 | pubmed:author | pubmed-author:VariakojisDD | lld:pubmed |
| pubmed-article:9454770 | pubmed:author | pubmed-author:JeffriesDD | lld:pubmed |
| pubmed-article:9454770 | pubmed:author | pubmed-author:GordonL ILI | lld:pubmed |
| pubmed-article:9454770 | pubmed:author | pubmed-author:AndersenJJ | lld:pubmed |
| pubmed-article:9454770 | pubmed:author | pubmed-author:BauerK DKD | lld:pubmed |
| pubmed-article:9454770 | pubmed:author | pubmed-author:WiltonDD | lld:pubmed |
| pubmed-article:9454770 | pubmed:author | pubmed-author:JiangSS | lld:pubmed |
| pubmed-article:9454770 | pubmed:author | pubmed-author:DomerPP | lld:pubmed |
| pubmed-article:9454770 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9454770 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9454770 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:9454770 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9454770 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9454770 | pubmed:pagination | 1391-8 | lld:pubmed |
| pubmed-article:9454770 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9454770 | pubmed:meshHeading | pubmed-meshheading:9454770-... | lld:pubmed |
| pubmed-article:9454770 | pubmed:meshHeading | pubmed-meshheading:9454770-... | lld:pubmed |
| pubmed-article:9454770 | pubmed:meshHeading | pubmed-meshheading:9454770-... | lld:pubmed |
| pubmed-article:9454770 | pubmed:meshHeading | pubmed-meshheading:9454770-... | lld:pubmed |
| pubmed-article:9454770 | pubmed:meshHeading | pubmed-meshheading:9454770-... | lld:pubmed |
| pubmed-article:9454770 | pubmed:meshHeading | pubmed-meshheading:9454770-... | lld:pubmed |
| pubmed-article:9454770 | pubmed:meshHeading | pubmed-meshheading:9454770-... | lld:pubmed |
| pubmed-article:9454770 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9454770 | pubmed:articleTitle | BCL-2 expression correlates with lower proliferative activity in the intermediate- and high-grade non-Hodgkin's lymphomas: an Eastern Cooperative Oncology Group and Southwest Oncology Group cooperative laboratory study. | lld:pubmed |
| pubmed-article:9454770 | pubmed:affiliation | Robert H. Lurie Cancer Center, Northwestern University, Chicago, IL 60611, USA. | lld:pubmed |
| pubmed-article:9454770 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9454770 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:9454770 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9454770 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:9454770 | pubmed:publicationType | Clinical Trial, Phase III | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9454770 | lld:pubmed |
