| pubmed-article:9453611 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9453611 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:9453611 | lifeskim:mentions | umls-concept:C0079720 | lld:lifeskim |
| pubmed-article:9453611 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9453611 | lifeskim:mentions | umls-concept:C0059387 | lld:lifeskim |
| pubmed-article:9453611 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9453611 | pubmed:dateCreated | 1998-2-12 | lld:pubmed |
| pubmed-article:9453611 | pubmed:abstractText | Staphylococcus aureus is a major mastitis-causing pathogen in cattle. The chronic nature of bovine staphylococcal mastitis suggests that some products or components of S. aureus may interfere with the development of protective immunity. One class of molecules that could be involved are superantigens (SAgs). Although a significant number of mastitis isolates produce SAgs, the effect of these molecules on the bovine immune system is unresolved. To determine if immunosuppression caused by SAgs could play a role in pathogenesis, we monitored bovine lymphocytes exposed to staphylococcal enterotoxin C1 (SEC1). Activation of bovine lymphocytes by either SEC1 or concanavalin A (ConA) was influenced by the gammadelta/alphabeta T-cell ratio in the culture. Compared to ConA-induced stimulation, cultures stimulated with SEC1 generated small numbers of CD4+ alphabeta T cells expressing high levels of interleukin-2 receptor alpha chain (IL-2R alpha) and major histocompatibility complex class II (MHCII), suggesting that SAg exposure does not lead to full activation of these cells. This state of partial activation was most pronounced in cultures with a high gammadelta/alphabeta ratio. In contrast, significant numbers of CD8+ alphabeta T cells expressed high levels of IL-2R alpha and MHCII, regardless of the gammadelta/alphabeta ratio and the stimulant used. CD8+ blasts in cultures stimulated with SEC1 also expressed another activation marker, ACT3, previously detected predominantly on thymocytes and CD4+ T cells. Although gammadelta CD2- and CD2+ T cells expressed MHCII and IL-2R alpha following stimulation with SEC1, only a few cells increased to blast size, suggesting that they were only partially activated. The results suggest ways in which SAgs might facilitate immunosuppression that promotes the persistence of bacteria in cattle and contributes to chronic intramammary infection. | lld:pubmed |
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| pubmed-article:9453611 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9453611 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9453611 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9453611 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9453611 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9453611 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9453611 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:9453611 | pubmed:author | pubmed-author:FoxLL | lld:pubmed |
| pubmed-article:9453611 | pubmed:author | pubmed-author:HamiltonM JMJ | lld:pubmed |
| pubmed-article:9453611 | pubmed:author | pubmed-author:DavisW CWC | lld:pubmed |
| pubmed-article:9453611 | pubmed:author | pubmed-author:ParkY HYH | lld:pubmed |
| pubmed-article:9453611 | pubmed:author | pubmed-author:FerensW AWA | lld:pubmed |
| pubmed-article:9453611 | pubmed:author | pubmed-author:DeobaldC FCF | lld:pubmed |
| pubmed-article:9453611 | pubmed:author | pubmed-author:BohachGG | lld:pubmed |
| pubmed-article:9453611 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9453611 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:9453611 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9453611 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9453611 | pubmed:pagination | 573-80 | lld:pubmed |
| pubmed-article:9453611 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9453611 | pubmed:meshHeading | pubmed-meshheading:9453611-... | lld:pubmed |
| pubmed-article:9453611 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9453611 | pubmed:articleTitle | Activation of bovine lymphocyte subpopulations by staphylococcal enterotoxin C. | lld:pubmed |
| pubmed-article:9453611 | pubmed:affiliation | Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow 83844, USA. | lld:pubmed |
| pubmed-article:9453611 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9453611 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9453611 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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