| pubmed-article:9449723 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9449723 | lifeskim:mentions | umls-concept:C0039195 | lld:lifeskim |
| pubmed-article:9449723 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9449723 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9449723 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9449723 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9449723 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9449723 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:9449723 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9449723 | pubmed:dateCreated | 1998-3-13 | lld:pubmed |
| pubmed-article:9449723 | pubmed:abstractText | The majority of T cell responses are restricted to peptide antigens bound by polymorphic major histocompatibility complex (MHC) molecules. However, peptide antigens can be presented to T cells by murine non-MHC-encoded CD1d (mCD1) molecules, and human T cell lines specific for nonpeptide antigens presented on CD1 isoforms have been identified. It is shown here that antigen-specific, mCD1-restricted lymphocytes can be generated in vivo by immunizing mice with a combination of plasmids encoding chicken ovalbumin, murine CD1d, and costimulatory molecules. Splenocytes from immunized mice have CD1d-restricted, MHC- unrestricted, ovalbumin-specific cytolytic activity that can be inhibited by anti-CD1 antibodies as well as a competing CD1-binding peptide. These results suggest a physiologic role for murine CD1d to present exogenous protein antigens. | lld:pubmed |
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| pubmed-article:9449723 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9449723 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449723 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9449723 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9449723 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9449723 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9449723 | pubmed:author | pubmed-author:LeeD JDJ | lld:pubmed |
| pubmed-article:9449723 | pubmed:author | pubmed-author:CarsonD ADA | lld:pubmed |
| pubmed-article:9449723 | pubmed:author | pubmed-author:CoryRR | lld:pubmed |
| pubmed-article:9449723 | pubmed:author | pubmed-author:AbeyratneAA | lld:pubmed |
| pubmed-article:9449723 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9449723 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:9449723 | pubmed:volume | 187 | lld:pubmed |
| pubmed-article:9449723 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9449723 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9449723 | pubmed:pagination | 433-8 | lld:pubmed |
| pubmed-article:9449723 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9449723 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9449723 | pubmed:articleTitle | Induction of an antigen-specific, CD1-restricted cytotoxic T lymphocyte response In vivo. | lld:pubmed |
| pubmed-article:9449723 | pubmed:affiliation | Department of Medicine and The Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, California 92093-0663, USA. | lld:pubmed |
| pubmed-article:9449723 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9449723 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9449723 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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