| pubmed-article:9449715 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9449715 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9449715 | lifeskim:mentions | umls-concept:C1326205 | lld:lifeskim |
| pubmed-article:9449715 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:9449715 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:9449715 | lifeskim:mentions | umls-concept:C1621296 | lld:lifeskim |
| pubmed-article:9449715 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9449715 | pubmed:dateCreated | 1998-3-13 | lld:pubmed |
| pubmed-article:9449715 | pubmed:abstractText | Activation, anergy, and apoptosis are all possible outcomes of T cell receptor (TCR) engagement. The first leads to proliferation and effector function, whereas the others can lead to partial or complete immunological tolerance. Structural variants of immunizing peptide-major histocompatibility complex molecule ligands that induce selective lymphokine secretion or anergy in mature T cells in association with altered intracellular signaling events have been described. Here we describe altered ligands for mature mouse CD4(+) T helper 1 cells that lead to T cell apoptosis by the selective expression of Fas ligand (FasL) and tumor necrosis factor (TNF) without concomitant IL-2, IL-3, or interferon gamma production. All ligands that stimulated cell death were found to induce FasL and TNF mRNA expression and TCR aggregation ("capping") at the cell surface, but did not elicit a common pattern of tyrosine phosphorylation of the TCR-associated signal transduction chains. Thus, TCR ligands that uniquely trigger T cell apoptosis without inducing cytokines that are normally associated with activation can be identified. | lld:pubmed |
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| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9449715 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9449715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9449715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9449715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9449715 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9449715 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9449715 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9449715 | pubmed:author | pubmed-author:GermainR NRN | lld:pubmed |
| pubmed-article:9449715 | pubmed:author | pubmed-author:LenardoM JMJ | lld:pubmed |
| pubmed-article:9449715 | pubmed:author | pubmed-author:Reis e... | lld:pubmed |
| pubmed-article:9449715 | pubmed:author | pubmed-author:CombadièreBB | lld:pubmed |
| pubmed-article:9449715 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9449715 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:9449715 | pubmed:volume | 187 | lld:pubmed |
| pubmed-article:9449715 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9449715 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9449715 | pubmed:pagination | 349-55 | lld:pubmed |
| pubmed-article:9449715 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9449715 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9449715 | pubmed:articleTitle | Selective induction of apoptosis in mature T lymphocytes by variant T cell receptor ligands. | lld:pubmed |
| pubmed-article:9449715 | pubmed:affiliation | Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:9449715 | pubmed:publicationType | Journal Article | lld:pubmed |
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