| pubmed-article:9449351 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9449351 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9449351 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:9449351 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:9449351 | lifeskim:mentions | umls-concept:C0085182 | lld:lifeskim |
| pubmed-article:9449351 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:9449351 | lifeskim:mentions | umls-concept:C1442080 | lld:lifeskim |
| pubmed-article:9449351 | lifeskim:mentions | umls-concept:C0012120 | lld:lifeskim |
| pubmed-article:9449351 | lifeskim:mentions | umls-concept:C1031041 | lld:lifeskim |
| pubmed-article:9449351 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9449351 | pubmed:dateCreated | 1998-4-2 | lld:pubmed |
| pubmed-article:9449351 | pubmed:abstractText | We have employed an interferometric technique for the local measurement of bending modulus, membrane tension, and adhesion energy of motile cells adhering to a substrate. Wild-type and mutant cells of Dictyostelium discoideum were incubated in a flow chamber. The flow-induced deformation of a cell near its adhesion area was determined by quantitative reflection interference contrast microscopy (RICM) and analyzed in terms of the elastic boundary conditions: equilibrium of tensions and bending moments at the contact line. This technique was employed to quantify changes caused by the lack of talin, a protein that couples the actin network to the plasma membrane, or by the lack of cortexillin I or II, two isoforms of the actin-bundling protein cortexillin. Cells lacking either cortexillin I or II exhibited reduced bending moduli of 95 and 160 k(B)T, respectively, as compared to 390 k(B)T, obtained for wild-type cells. No significant difference was found for the adhesion energies of wild-type and cortexillin mutant cells. In cells lacking talin, not only a strongly reduced bending modulus of 70 k(B)T, but also a low adhesion energy one-fourth of that in wild-type cells was measured. | lld:pubmed |
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| pubmed-article:9449351 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9449351 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9449351 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9449351 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9449351 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9449351 | pubmed:issn | 0006-3495 | lld:pubmed |
| pubmed-article:9449351 | pubmed:author | pubmed-author:GerischGG | lld:pubmed |
| pubmed-article:9449351 | pubmed:author | pubmed-author:SackmannEE | lld:pubmed |
| pubmed-article:9449351 | pubmed:author | pubmed-author:SimsonRR | lld:pubmed |
| pubmed-article:9449351 | pubmed:author | pubmed-author:FaixJJ | lld:pubmed |
| pubmed-article:9449351 | pubmed:author | pubmed-author:WallraffEE | lld:pubmed |
| pubmed-article:9449351 | pubmed:author | pubmed-author:NiewöhnerJJ | lld:pubmed |
| pubmed-article:9449351 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9449351 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:9449351 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9449351 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9449351 | pubmed:pagination | 514-22 | lld:pubmed |
| pubmed-article:9449351 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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| pubmed-article:9449351 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9449351 | pubmed:articleTitle | Membrane bending modulus and adhesion energy of wild-type and mutant cells of Dictyostelium lacking talin or cortexillins. | lld:pubmed |
| pubmed-article:9449351 | pubmed:affiliation | Physics Department, Technische Universität München, Garching, Germany. rsimson@physik.tu-muenchen.de | lld:pubmed |
| pubmed-article:9449351 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9449351 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9449351 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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