| pubmed-article:9437998 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9437998 | lifeskim:mentions | umls-concept:C0494165 | lld:lifeskim |
| pubmed-article:9437998 | lifeskim:mentions | umls-concept:C1527249 | lld:lifeskim |
| pubmed-article:9437998 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9437998 | lifeskim:mentions | umls-concept:C0033713 | lld:lifeskim |
| pubmed-article:9437998 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:9437998 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9437998 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9437998 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:9437998 | pubmed:dateCreated | 1998-2-2 | lld:pubmed |
| pubmed-article:9437998 | pubmed:abstractText | We have examined the expression of c-met mRNA in tissue from 27 colorectal cancers and ten liver metastases using the reverse transcriptase-polymerase chain reaction method. The expression of c-met mRNA in these tissues was quantified and the copy number of c-met mRNA to 10(8.0) copies of beta-actin mRNA was calculated. Mean copy numbers of c-met mRNA in cancer tissue and normal mucosa were 10(5.5) and 10(4.5) respectively. The c-met expression of cancer was significantly higher than that of normal mucosa (P < 0.0001). In 20 of 22 samples in which c-met expression of both tumor and corresponding normal tissue were examined, c-met was overexpressed in the cancer tissue. No correlation was found between c-met expression and the clinicopathologic background. The mean copy numbers of c-met mRNA in the tissue from the ten liver metastases and normal liver were 10(6.1) and 10(6.2) respectively. Although c-met expression in metastatic tissue was higher than that in the primary cancer tissue, the increase was not statistically significant. In three of four patients with synchronous liver metastases, c-met was overexpressed in the metastatic tissue compared with that in the corresponding primary cancer tissue. These results show that c-met is overexpressed in both primary colorectal cancer and liver metastases and suggest that c-met plays a role in the development of colorectal cancer liver metastases. | lld:pubmed |
| pubmed-article:9437998 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9437998 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9437998 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9437998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9437998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9437998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9437998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9437998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9437998 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9437998 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9437998 | pubmed:issn | 0368-2811 | lld:pubmed |
| pubmed-article:9437998 | pubmed:author | pubmed-author:FujitaSS | lld:pubmed |
| pubmed-article:9437998 | pubmed:author | pubmed-author:SuganoKK | lld:pubmed |
| pubmed-article:9437998 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9437998 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:9437998 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9437998 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9437998 | pubmed:pagination | 378-83 | lld:pubmed |
| pubmed-article:9437998 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:9437998 | pubmed:meshHeading | pubmed-meshheading:9437998-... | lld:pubmed |
| pubmed-article:9437998 | pubmed:meshHeading | pubmed-meshheading:9437998-... | lld:pubmed |
| pubmed-article:9437998 | pubmed:meshHeading | pubmed-meshheading:9437998-... | lld:pubmed |
| pubmed-article:9437998 | pubmed:meshHeading | pubmed-meshheading:9437998-... | lld:pubmed |
| pubmed-article:9437998 | pubmed:meshHeading | pubmed-meshheading:9437998-... | lld:pubmed |
| pubmed-article:9437998 | pubmed:meshHeading | pubmed-meshheading:9437998-... | lld:pubmed |
| pubmed-article:9437998 | pubmed:meshHeading | pubmed-meshheading:9437998-... | lld:pubmed |
| pubmed-article:9437998 | pubmed:meshHeading | pubmed-meshheading:9437998-... | lld:pubmed |
| pubmed-article:9437998 | pubmed:meshHeading | pubmed-meshheading:9437998-... | lld:pubmed |
| pubmed-article:9437998 | pubmed:meshHeading | pubmed-meshheading:9437998-... | lld:pubmed |
| pubmed-article:9437998 | pubmed:meshHeading | pubmed-meshheading:9437998-... | lld:pubmed |
| pubmed-article:9437998 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9437998 | pubmed:articleTitle | Expression of c-met proto-oncogene in primary colorectal cancer and liver metastases. | lld:pubmed |
| pubmed-article:9437998 | pubmed:affiliation | Department of Surgery, National Cancer Center Hospital, Tokyo, Japan. | lld:pubmed |
| pubmed-article:9437998 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9437998 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9437998 | lld:pubmed |
