| pubmed-article:9436464 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9436464 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:9436464 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:9436464 | lifeskim:mentions | umls-concept:C1413246 | lld:lifeskim |
| pubmed-article:9436464 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9436464 | pubmed:dateCreated | 1998-2-11 | lld:pubmed |
| pubmed-article:9436464 | pubmed:abstractText | Our previous study demonstrated that CD9 is expressed on most mature naive T-cells and delivers a potent costimulatory signal that functions independently of CD28. Here, we investigated whether this CD9-mediated signal is different from the CD28-mediated signal in the mode of costimulation and whether both signals function synergistically for T-cell activation. Anti-CD9 or anti-CD28 monoclonal antibody (mAb) increased [3H]TdR incorporation of naive T-cells in the absence of antigen-presenting cells (APC) when coimmobilized with submitogenic doses of anti-CD3 mAb. The levels of costimulation induced by ligation of CD9 and CD28 were comparable. However, the costimulatory effect differed between soluble anti-CD9 and CD28 mAb. A soluble form of anti-CD28 mAb could costimulate anti-CD3-triggered T-cells, whereas soluble anti-CD9 mAb failed to costimulate. Although anti-CD28 costimulated naive T-cells treated with phorbol myristate acetate (PMA) instead of anti-CD3 mAb, a combination of PMA plus anti-CD9 mAb could not induce T-cell activation. The combined costimulation of anti-CD3-triggered T-cells with anti-CD9 and anti-CD28 mAbs resulted in strikingly enhanced [3H]TdR uptake and lymphokine (IL-2 and IFN-gamma) production when compared to those induced by each costimulation. These results suggest that CD9 and CD28 induce T-cell costimulation using different signaling pathways, thereby inducing synergy in T-cell activation. | lld:pubmed |
| pubmed-article:9436464 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9436464 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9436464 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9436464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9436464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9436464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9436464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9436464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9436464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9436464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9436464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9436464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9436464 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9436464 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9436464 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9436464 | pubmed:issn | 0165-2478 | lld:pubmed |
| pubmed-article:9436464 | pubmed:author | pubmed-author:KEYY | lld:pubmed |
| pubmed-article:9436464 | pubmed:author | pubmed-author:KobayashiMM | lld:pubmed |
| pubmed-article:9436464 | pubmed:author | pubmed-author:FujiwaraHH | lld:pubmed |
| pubmed-article:9436464 | pubmed:author | pubmed-author:HamaokaTT | lld:pubmed |
| pubmed-article:9436464 | pubmed:author | pubmed-author:AbeRR | lld:pubmed |
| pubmed-article:9436464 | pubmed:author | pubmed-author:WooV LVL | lld:pubmed |
| pubmed-article:9436464 | pubmed:author | pubmed-author:YashiroYY | lld:pubmed |
| pubmed-article:9436464 | pubmed:author | pubmed-author:NebelUU | lld:pubmed |
| pubmed-article:9436464 | pubmed:author | pubmed-author:Toyo-okaKK | lld:pubmed |
| pubmed-article:9436464 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9436464 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:9436464 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9436464 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9436464 | pubmed:pagination | 19-23 | lld:pubmed |
| pubmed-article:9436464 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:9436464 | pubmed:meshHeading | pubmed-meshheading:9436464-... | lld:pubmed |
| pubmed-article:9436464 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9436464 | pubmed:articleTitle | Synergy between CD28 and CD9 costimulation for naive T-cell activation. | lld:pubmed |
| pubmed-article:9436464 | pubmed:affiliation | Biomedical Research Center, Osaka University Medical School, Japan. | lld:pubmed |
| pubmed-article:9436464 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9436464 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12487 | entrezgene:pubmed | pubmed-article:9436464 | lld:entrezgene |
| entrez-gene:12527 | entrezgene:pubmed | pubmed-article:9436464 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9436464 | lld:pubmed |
