| pubmed-article:9416506 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9416506 | lifeskim:mentions | umls-concept:C0597404 | lld:lifeskim |
| pubmed-article:9416506 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:9416506 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:9416506 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:9416506 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:9416506 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:9416506 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:9416506 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:9416506 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:9416506 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:9416506 | pubmed:dateCreated | 1998-2-24 | lld:pubmed |
| pubmed-article:9416506 | pubmed:abstractText | The rules for T-cell-mediated control of viruses that infect via the respiratory mucosae show both common themes and differences, depending on the nature of the pathogen. Virus-specific CD8+ cytotoxic T lymphocytes (CTLs) are the key effectors of virus clearance in mice infected with both negative strand RNA viruses (influenza and Sendai) and a DNA virus, the murine gamma-herpesvirus-68 (MHV-68). Recently completed experiments establish that these activated CD8+ T cells indeed operate primarily via contact-dependent lysis. Perforin-mediated cytotoxicity seems to be the preferred mode, though a Fas-based mechanism can apparently serve as an alternative mechanism. Immune CD4+ T cells functioning in the absence of the CD8+ subset cannot eliminate MHV-68 from lung epithelial cells, are somewhat less efficient than the CD8+ CTLs at clearing the RNA viruses, and are generally ineffectual in mice that lack B lymphocytes. Though cytokine secretion by CD4+ and CD8+ T cells in the virus-infected lung may promote both T-cell extravasation and macrophage activation, such processes are not alone sufficient to deal consistently with any of these infections. However, CD4+ T help is mandatory for an effective B-cell response, and can operate to promote the clonal expansion of virus-specific CD8+ T cells in the lymph nodes and spleen. Furthermore, a concurrent CD4+ T-cell response seems to be essential for maintaining continued CD8+ T-cell surveillance and effector capacity through the persistent, latent phase of MHV-68 infection in B cells. Thus, the evidence to date supports a very traditional view; CD8+ T cells function mainly as killers and the CD4+ T cells as helpers in these respiratory virus infections. | lld:pubmed |
| pubmed-article:9416506 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9416506 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9416506 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9416506 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9416506 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9416506 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9416506 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9416506 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9416506 | pubmed:issn | 0105-2896 | lld:pubmed |
| pubmed-article:9416506 | pubmed:author | pubmed-author:DohertyP CPC | lld:pubmed |
| pubmed-article:9416506 | pubmed:author | pubmed-author:BrooksJ WJW | lld:pubmed |
| pubmed-article:9416506 | pubmed:author | pubmed-author:StevensonP... | lld:pubmed |
| pubmed-article:9416506 | pubmed:author | pubmed-author:TophamD JDJ | lld:pubmed |
| pubmed-article:9416506 | pubmed:author | pubmed-author:CardinR DRD | lld:pubmed |
| pubmed-article:9416506 | pubmed:author | pubmed-author:TrippR ARA | lld:pubmed |
| pubmed-article:9416506 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9416506 | pubmed:volume | 159 | lld:pubmed |
| pubmed-article:9416506 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9416506 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9416506 | pubmed:pagination | 105-17 | lld:pubmed |
| pubmed-article:9416506 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9416506 | pubmed:meshHeading | pubmed-meshheading:9416506-... | lld:pubmed |
| pubmed-article:9416506 | pubmed:meshHeading | pubmed-meshheading:9416506-... | lld:pubmed |
| pubmed-article:9416506 | pubmed:meshHeading | pubmed-meshheading:9416506-... | lld:pubmed |
| pubmed-article:9416506 | pubmed:meshHeading | pubmed-meshheading:9416506-... | lld:pubmed |
| pubmed-article:9416506 | pubmed:meshHeading | pubmed-meshheading:9416506-... | lld:pubmed |
| pubmed-article:9416506 | pubmed:meshHeading | pubmed-meshheading:9416506-... | lld:pubmed |
| pubmed-article:9416506 | pubmed:meshHeading | pubmed-meshheading:9416506-... | lld:pubmed |
| pubmed-article:9416506 | pubmed:meshHeading | pubmed-meshheading:9416506-... | lld:pubmed |
| pubmed-article:9416506 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9416506 | pubmed:articleTitle | Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections. | lld:pubmed |
| pubmed-article:9416506 | pubmed:affiliation | St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. peter.doherty@stjude.org | lld:pubmed |
| pubmed-article:9416506 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9416506 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9416506 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:9416506 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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