| pubmed-article:9412578 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9412578 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:9412578 | lifeskim:mentions | umls-concept:C0273115 | lld:lifeskim |
| pubmed-article:9412578 | lifeskim:mentions | umls-concept:C0005740 | lld:lifeskim |
| pubmed-article:9412578 | lifeskim:mentions | umls-concept:C0062534 | lld:lifeskim |
| pubmed-article:9412578 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:9412578 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9412578 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:9412578 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:9412578 | lifeskim:mentions | umls-concept:C0205421 | lld:lifeskim |
| pubmed-article:9412578 | lifeskim:mentions | umls-concept:C0521115 | lld:lifeskim |
| pubmed-article:9412578 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:9412578 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:9412578 | pubmed:dateCreated | 1998-1-14 | lld:pubmed |
| pubmed-article:9412578 | pubmed:abstractText | Hepatocyte growth factor (HGF) is a humoral mediator of epithelial-mesenchymal interactions, acting on a variety of epithelial cells as mitogen, motogen, and morphogen. Exogenous HGF acts as a hepatotrophic factor and a renotrophic factor during experimental injury. To investigate whether HGF has a pulmotrophic function, human recombinant HGF was administered to C57BL/6 mice with severe lung injury by bleomycin (BLM). Low dose simultaneous and continuous administration of HGF (50 micrograms/mouse/7 d) with BLM (100 mg/mouse/7 d) repressed fibrotic morphological changes at 2 and 4 wk. Ashcroft score showed a significant difference in lung fibrosis with and without HGF at 4 wk (3.7 +/- 0.4 versus 4.9 +/- 0.3, p < 0.05). Furthermore, either simultaneous or delayed administration of high dose HGF (280 micrograms/mouse/14 d) equally repressed fibrotic changes by BLM when examined at 4 wk (Ashcroft score: 2.6 +/- 0.4 and 2.4 +/- 0.2 versus 4.1 +/- 0.2, p < 0.01). Hydroxyproline content in the lungs was significantly lower in mice with either simultaneous or delayed administration of high dose HGF as compared to those administered BLM alone (121.8 +/- 8.1% and 113.2 +/- 6.2% versus 162.7 +/- 4.6%, p < 0.001). These findings indicate that exogenous HGF acts as a pulmotrophic factor in vivo and prevents the progression of BLM-induced lung injury when administered in either a simultaneous or delayed fashion. HGF may be a potent candidate to prevent or treat lung fibrosis. | lld:pubmed |
| pubmed-article:9412578 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9412578 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9412578 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9412578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9412578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9412578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9412578 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9412578 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9412578 | pubmed:issn | 1073-449X | lld:pubmed |
| pubmed-article:9412578 | pubmed:author | pubmed-author:AbeTT | lld:pubmed |
| pubmed-article:9412578 | pubmed:author | pubmed-author:TakahashiTT | lld:pubmed |
| pubmed-article:9412578 | pubmed:author | pubmed-author:NakamuraTT | lld:pubmed |
| pubmed-article:9412578 | pubmed:author | pubmed-author:MatsumotoKK | lld:pubmed |
| pubmed-article:9412578 | pubmed:author | pubmed-author:SakaiTT | lld:pubmed |
| pubmed-article:9412578 | pubmed:author | pubmed-author:OhnumaKK | lld:pubmed |
| pubmed-article:9412578 | pubmed:author | pubmed-author:SatohKK | lld:pubmed |
| pubmed-article:9412578 | pubmed:author | pubmed-author:NakayamaSS | lld:pubmed |
| pubmed-article:9412578 | pubmed:author | pubmed-author:NukiwaTT | lld:pubmed |
| pubmed-article:9412578 | pubmed:author | pubmed-author:YaekashiwaMM | lld:pubmed |
| pubmed-article:9412578 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9412578 | pubmed:volume | 156 | lld:pubmed |
| pubmed-article:9412578 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9412578 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9412578 | pubmed:pagination | 1937-44 | lld:pubmed |
| pubmed-article:9412578 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9412578 | pubmed:meshHeading | pubmed-meshheading:9412578-... | lld:pubmed |
| pubmed-article:9412578 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9412578 | pubmed:articleTitle | Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin. A morphologic study. | lld:pubmed |
| pubmed-article:9412578 | pubmed:affiliation | Department of Respiratory Oncology and Molecular Medicine, Tohoku University, Sendai, Japan. yaesan@idac.tohoku.ac.jp | lld:pubmed |
| pubmed-article:9412578 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9412578 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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