| pubmed-article:9408008 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9408008 | lifeskim:mentions | umls-concept:C1882714 | lld:lifeskim |
| pubmed-article:9408008 | lifeskim:mentions | umls-concept:C0082341 | lld:lifeskim |
| pubmed-article:9408008 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:9408008 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:9408008 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9408008 | pubmed:dateCreated | 1998-1-14 | lld:pubmed |
| pubmed-article:9408008 | pubmed:abstractText | The pharmacological profile and the microanatomical localisation of a putative dopamine D3 receptor in the rat renal cortex were investigated using radioligand binding assay and light microscope autoradiography techniques. [3H]7-hydroxy-N,N-di-n-propyl-2-aminotetraline ([3H]7-OH-DPAT) was used as a ligand. [3H]7-OH-DPAT was bound specifically to sections of renal cortex. The binding was time-, temperature- and concentration-dependent, of high affinity and guanine nucleotide-insensitive. The dissociation constant (Kd) value was 0.57 +/- 0.02 nM and the maximum density of binding sites (Bmax) was 62.4 +/- 3.5 fmol/mg tissue. The pharmacological profile of [3H]7-OH-DPAT binding to sections of rat renal cortex suggests the labelling of a dopamine D3 receptor. Light microscope autoradiography revealed the accumulation of the radioligand primarily within cortical tubules and to a lesser extent in the glomerular tuft. In glomeruli, binding sites were found mainly in mesangium and mesangial cells. The demonstration of a putative dopamine D3 receptor in slide-mounted sections of rat renal cortex suggests that appropriate radioligand binding assay techniques combined with autoradiography, may contribute to characterise peripheral dopamine receptor subtypes. | lld:pubmed |
| pubmed-article:9408008 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9408008 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9408008 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9408008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9408008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9408008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9408008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9408008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9408008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9408008 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9408008 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9408008 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:9408008 | pubmed:author | pubmed-author:AmentaFF | lld:pubmed |
| pubmed-article:9408008 | pubmed:author | pubmed-author:RicciAA | lld:pubmed |
| pubmed-article:9408008 | pubmed:author | pubmed-author:BaldoniEE | lld:pubmed |
| pubmed-article:9408008 | pubmed:author | pubmed-author:BarileLL | lld:pubmed |
| pubmed-article:9408008 | pubmed:author | pubmed-author:MigniniFF | lld:pubmed |
| pubmed-article:9408008 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9408008 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:9408008 | pubmed:volume | 338 | lld:pubmed |
| pubmed-article:9408008 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9408008 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9408008 | pubmed:pagination | 89-95 | lld:pubmed |
| pubmed-article:9408008 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9408008 | pubmed:meshHeading | pubmed-meshheading:9408008-... | lld:pubmed |
| pubmed-article:9408008 | pubmed:meshHeading | pubmed-meshheading:9408008-... | lld:pubmed |
| pubmed-article:9408008 | pubmed:meshHeading | pubmed-meshheading:9408008-... | lld:pubmed |
| pubmed-article:9408008 | pubmed:meshHeading | pubmed-meshheading:9408008-... | lld:pubmed |
| pubmed-article:9408008 | pubmed:meshHeading | pubmed-meshheading:9408008-... | lld:pubmed |
| pubmed-article:9408008 | pubmed:meshHeading | pubmed-meshheading:9408008-... | lld:pubmed |
| pubmed-article:9408008 | pubmed:meshHeading | pubmed-meshheading:9408008-... | lld:pubmed |
| pubmed-article:9408008 | pubmed:meshHeading | pubmed-meshheading:9408008-... | lld:pubmed |
| pubmed-article:9408008 | pubmed:meshHeading | pubmed-meshheading:9408008-... | lld:pubmed |
| pubmed-article:9408008 | pubmed:meshHeading | pubmed-meshheading:9408008-... | lld:pubmed |
| pubmed-article:9408008 | pubmed:meshHeading | pubmed-meshheading:9408008-... | lld:pubmed |
| pubmed-article:9408008 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9408008 | pubmed:articleTitle | Pharmacological characterisation and autoradiographic localisation of a putative dopamine D3 receptor in the rat kidney. | lld:pubmed |
| pubmed-article:9408008 | pubmed:affiliation | Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Università di Camerino, Italy. | lld:pubmed |
| pubmed-article:9408008 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9408008 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
