| pubmed-article:9407562 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9407562 | lifeskim:mentions | umls-concept:C0004096 | lld:lifeskim |
| pubmed-article:9407562 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:9407562 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:9407562 | lifeskim:mentions | umls-concept:C0034819 | lld:lifeskim |
| pubmed-article:9407562 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:9407562 | lifeskim:mentions | umls-concept:C0950373 | lld:lifeskim |
| pubmed-article:9407562 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:9407562 | lifeskim:mentions | umls-concept:C1521725 | lld:lifeskim |
| pubmed-article:9407562 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9407562 | pubmed:dateCreated | 1998-1-8 | lld:pubmed |
| pubmed-article:9407562 | pubmed:abstractText | The hypotheses tested in this study were that during acute asthma exacerbations (1) exhaled nitric oxide concentrations [eNO] are a more sensitive, noninvasive indicator of asthma disease activity than serum markers of inflammation such as eosinophil cationic protein (ECP) or soluble interleukin 2 receptor (sIL2R), and (2) elevated [eNO] are reduced after treatment with glucocorticoids (GC). Peak eNO levels were measured by chemiluminescence during slow expiration. Seven asthmatic subjects (mean age 11 yrs; mean morning FEV1 65% predicted) receiving inhaled GC, and with no radiographic evidence of acute sinusitis, were studied before and after a course of oral GC. Measurements of [eNO], ECP and sIL2R levels, and FEV1% were obtained before and after a course of GC. Six atopic nonasthmatic subjects (mean age 12 years; mean FEV1 94% predicted) and seven normal subjects (mean age 13 years; mean FEV1 100% predicted) were studied. The mean peak [eNO] level (parts per billion: ppb) for the asthma subjects before treatment (52 +/- 5 ppb SEM) was greater than the value for both nonasthmatic atopic and normal subjects (16 +/- 2 ppb and 14 +/- 2 ppb SEM, respectively; P < 0.0001). There was no significant difference in ECP or sIL2R values between asthmatic subjects and either atopic or normal subjects (P > 0.05). Baseline pre-GC treatment ECP levels in the asthmatic subjects were significantly higher (P < 0.002) than post-GC treatment values. The mean peak [eNO] level in the asthmatic subjects declined after oral GC treatment to 14 +/- 1 ppb (P < 0.0002) and was less than 2 ppb different from either control group (P > 0.75). We conclude that [eNO] is a more sensitive marker of asthma disease activity than ECP and sIL2R levels. In addition, [eNO] appears to be a more useful indicator of the beneficial response to GC therapy than these other measurements in pediatric asthma. | lld:pubmed |
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| pubmed-article:9407562 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9407562 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9407562 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9407562 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9407562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9407562 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9407562 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9407562 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9407562 | pubmed:issn | 8755-6863 | lld:pubmed |
| pubmed-article:9407562 | pubmed:author | pubmed-author:WhiteC WCW | lld:pubmed |
| pubmed-article:9407562 | pubmed:author | pubmed-author:LeungD YDY | lld:pubmed |
| pubmed-article:9407562 | pubmed:author | pubmed-author:HarbeckRR | lld:pubmed |
| pubmed-article:9407562 | pubmed:author | pubmed-author:SzeflerS JSJ | lld:pubmed |
| pubmed-article:9407562 | pubmed:author | pubmed-author:NongLL | lld:pubmed |
| pubmed-article:9407562 | pubmed:author | pubmed-author:McCormickD... | lld:pubmed |
| pubmed-article:9407562 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9407562 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:9407562 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9407562 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9407562 | pubmed:pagination | 305-11 | lld:pubmed |
| pubmed-article:9407562 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9407562 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9407562 | pubmed:articleTitle | Comparison of exhaled nitric oxide, serum eosinophilic cationic protein, and soluble interleukin-2 receptor in exacerbations of pediatric asthma. | lld:pubmed |
| pubmed-article:9407562 | pubmed:affiliation | Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA. | lld:pubmed |
| pubmed-article:9407562 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9407562 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9407562 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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