| pubmed-article:9405225 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9405225 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9405225 | lifeskim:mentions | umls-concept:C0227651 | lld:lifeskim |
| pubmed-article:9405225 | lifeskim:mentions | umls-concept:C0387583 | lld:lifeskim |
| pubmed-article:9405225 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9405225 | lifeskim:mentions | umls-concept:C0048897 | lld:lifeskim |
| pubmed-article:9405225 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9405225 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9405225 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9405225 | pubmed:dateCreated | 1998-1-15 | lld:pubmed |
| pubmed-article:9405225 | pubmed:abstractText | Tetrahydrobiopterin (BH4) biosynthetic pathways are stimulated under inflammatory conditions. The newly synthesized BH4 serves as a cofactor for optimal activity of inducible nitric oxide synthase (NOS2). In human mesangial cells (HMC), BH4 is also a limiting factor for NOS2 expression. In this study we show that BH4 availability can also play a modulatory role in the expression of cyclooxygenase 2 (COX-2) in HMC. Supplementing HMC with the BH4 donor sepiapterin potentiated IL-1beta/TNF-alpha-induced COX-2 expression by approximately 2-fold. This effect was abolished by methotrexate. In contrast, the NOS inhibitor L-NAME and the soluble guanylate cyclase inhibitor ODQ did not block sepiapterin amplification of COX-2 expression. Moreover, sepiapterin was found to modulate the tyrosine phosphorylation of several cellular substrates, an early event which occurred well before the induction of NOS2 could be evidenced. These findings suggest a role for BH4 in the modulation of mesangial cell responses to pro-inflammatory stimuli. | lld:pubmed |
| pubmed-article:9405225 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9405225 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9405225 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9405225 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9405225 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:9405225 | pubmed:author | pubmed-author:RonMM | lld:pubmed |
| pubmed-article:9405225 | pubmed:author | pubmed-author:LamasSS | lld:pubmed |
| pubmed-article:9405225 | pubmed:author | pubmed-author:JiménezWW | lld:pubmed |
| pubmed-article:9405225 | pubmed:author | pubmed-author:Pérez-SalaDD | lld:pubmed |
| pubmed-article:9405225 | pubmed:author | pubmed-author:Díaz-CazorlaM... | lld:pubmed |
| pubmed-article:9405225 | pubmed:copyrightInfo | Copyright 1997 Academic Press. | lld:pubmed |
| pubmed-article:9405225 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9405225 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:9405225 | pubmed:volume | 241 | lld:pubmed |
| pubmed-article:9405225 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9405225 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9405225 | pubmed:pagination | 7-12 | lld:pubmed |
| pubmed-article:9405225 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9405225 | pubmed:meshHeading | pubmed-meshheading:9405225-... | lld:pubmed |
| pubmed-article:9405225 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9405225 | pubmed:articleTitle | Tetrahydrobiopterin modulates cyclooxygenase-2 expression in human mesangial cells. | lld:pubmed |
| pubmed-article:9405225 | pubmed:affiliation | Instituto "Reina Sofía" de Investigaciones Nefrológicas, C.S.I.C., Velázquez 144, Madrid, 28006, Spain. lperezsala@fresno.csic.es | lld:pubmed |
| pubmed-article:9405225 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9405225 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
