| pubmed-article:9402326 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9402326 | lifeskim:mentions | umls-concept:C0008976 | lld:lifeskim |
| pubmed-article:9402326 | lifeskim:mentions | umls-concept:C0243020 | lld:lifeskim |
| pubmed-article:9402326 | lifeskim:mentions | umls-concept:C0175659 | lld:lifeskim |
| pubmed-article:9402326 | lifeskim:mentions | umls-concept:C0349674 | lld:lifeskim |
| pubmed-article:9402326 | lifeskim:mentions | umls-concept:C0870840 | lld:lifeskim |
| pubmed-article:9402326 | lifeskim:mentions | umls-concept:C0071321 | lld:lifeskim |
| pubmed-article:9402326 | lifeskim:mentions | umls-concept:C0222045 | lld:lifeskim |
| pubmed-article:9402326 | pubmed:issue | 3-4 | lld:pubmed |
| pubmed-article:9402326 | pubmed:dateCreated | 1998-1-29 | lld:pubmed |
| pubmed-article:9402326 | pubmed:abstractText | We have conjugated the murine monoclonal anti-CD7 antibody TXU to the plant hemitoxin pokeweed antiviral protein (PAP) to construct an effective immunotoxin against CD7 antigen positive hematologic malignancies. The scaled-up production and purification of TXU antibody, PAP toxin, and TXU-PAP immunotoxin permitted the manufacturing of a highly purified clinical-grade TXU-PAP preparation. In clonogenic assays, TXU-PAP elicited selective and potent cytotoxicity against CD7 antigen positive human leukemia cells and killed primary clonogenic leukemic cells from T-lineage acute lymphoblastic leukemia (ALL) patients. To our knowledge, this pre-IND work represents the first effort of producing a clinical-grade PAP immunotoxin for treatment of T-lineage ALL. Since the CD7 antigen is also expressed on AML cells, TXU-PAP could also be useful for the treatment of CD7 positive acute myeloid leukemia (AML) patients. | lld:pubmed |
| pubmed-article:9402326 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9402326 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9402326 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9402326 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9402326 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9402326 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9402326 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9402326 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9402326 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9402326 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9402326 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9402326 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9402326 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9402326 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9402326 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9402326 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9402326 | pubmed:issn | 1042-8194 | lld:pubmed |
| pubmed-article:9402326 | pubmed:author | pubmed-author:HoffmanNN | lld:pubmed |
| pubmed-article:9402326 | pubmed:author | pubmed-author:BellKK | lld:pubmed |
| pubmed-article:9402326 | pubmed:author | pubmed-author:TurnerNN | lld:pubmed |
| pubmed-article:9402326 | pubmed:author | pubmed-author:MyersD EDE | lld:pubmed |
| pubmed-article:9402326 | pubmed:author | pubmed-author:UckunF MFM | lld:pubmed |
| pubmed-article:9402326 | pubmed:author | pubmed-author:DonelsonRR | lld:pubmed |
| pubmed-article:9402326 | pubmed:author | pubmed-author:LanglieM CMC | lld:pubmed |
| pubmed-article:9402326 | pubmed:author | pubmed-author:JunXX | lld:pubmed |
| pubmed-article:9402326 | pubmed:author | pubmed-author:ClementsonDD | lld:pubmed |
| pubmed-article:9402326 | pubmed:author | pubmed-author:SarquisMM | lld:pubmed |
| pubmed-article:9402326 | pubmed:author | pubmed-author:SichenederAA | lld:pubmed |
| pubmed-article:9402326 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9402326 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:9402326 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9402326 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9402326 | pubmed:pagination | 275-302 | lld:pubmed |
| pubmed-article:9402326 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9402326 | pubmed:meshHeading | pubmed-meshheading:9402326-... | lld:pubmed |
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| pubmed-article:9402326 | pubmed:meshHeading | pubmed-meshheading:9402326-... | lld:pubmed |
| pubmed-article:9402326 | pubmed:meshHeading | pubmed-meshheading:9402326-... | lld:pubmed |
| pubmed-article:9402326 | pubmed:meshHeading | pubmed-meshheading:9402326-... | lld:pubmed |
| pubmed-article:9402326 | pubmed:meshHeading | pubmed-meshheading:9402326-... | lld:pubmed |
| pubmed-article:9402326 | pubmed:meshHeading | pubmed-meshheading:9402326-... | lld:pubmed |
| pubmed-article:9402326 | pubmed:meshHeading | pubmed-meshheading:9402326-... | lld:pubmed |
| pubmed-article:9402326 | pubmed:meshHeading | pubmed-meshheading:9402326-... | lld:pubmed |
| pubmed-article:9402326 | pubmed:meshHeading | pubmed-meshheading:9402326-... | lld:pubmed |
| pubmed-article:9402326 | pubmed:meshHeading | pubmed-meshheading:9402326-... | lld:pubmed |
| pubmed-article:9402326 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9402326 | pubmed:articleTitle | Large scale manufacturing of TXU(anti-CD7)-pokeweed antiviral protein (PAP) immunoconjugate for clinical trials. | lld:pubmed |
| pubmed-article:9402326 | pubmed:affiliation | Hughes Institute, St. Paul, Minnesota 55113, USA. | lld:pubmed |
| pubmed-article:9402326 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9402326 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9402326 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:9402326 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9402326 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9402326 | lld:pubmed |
