| pubmed-article:9398632 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9398632 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:9398632 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:9398632 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:9398632 | lifeskim:mentions | umls-concept:C0003595 | lld:lifeskim |
| pubmed-article:9398632 | lifeskim:mentions | umls-concept:C1550101 | lld:lifeskim |
| pubmed-article:9398632 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:9398632 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:9398632 | lifeskim:mentions | umls-concept:C1100714 | lld:lifeskim |
| pubmed-article:9398632 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9398632 | pubmed:dateCreated | 1998-1-13 | lld:pubmed |
| pubmed-article:9398632 | pubmed:abstractText | The inheritance of the apolipoprotein (apo) E4 allele is an important risk factor for late-onset Alzheimer's disease (AD). A major component of the Alzheimer's disease neuritic plaques is amyloid beta (A beta). We previously identified apoE/A beta complexes within neuritic plaques (1). It was not known if this interaction takes place before or after A beta peptides become incorporated into neuritic plaques. To address this question we sought evidence of apoE complexes with brain soluble A beta peptides in AD and control patients. In addition, numerous proteins have been shown to bind A beta peptides in vitro. It is not know if any of these bind brain sA beta in vivo. We found evidence for the presence of apoE/dimeric sA beta complexes in the AD brain and could not detect complexes with other A beta peptide binding proteins. The binding of sA beta to apoE may be one factor influencing its clearance from the brain and/or its conformational state. | lld:pubmed |
| pubmed-article:9398632 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9398632 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9398632 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9398632 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9398632 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9398632 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9398632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9398632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9398632 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9398632 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9398632 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:9398632 | pubmed:author | pubmed-author:FrangioneBB | lld:pubmed |
| pubmed-article:9398632 | pubmed:author | pubmed-author:PerezCC | lld:pubmed |
| pubmed-article:9398632 | pubmed:author | pubmed-author:WisniewskiTT | lld:pubmed |
| pubmed-article:9398632 | pubmed:author | pubmed-author:SotoCC | lld:pubmed |
| pubmed-article:9398632 | pubmed:author | pubmed-author:PermanneBB | lld:pubmed |
| pubmed-article:9398632 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9398632 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:9398632 | pubmed:volume | 240 | lld:pubmed |
| pubmed-article:9398632 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9398632 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9398632 | pubmed:pagination | 715-20 | lld:pubmed |
| pubmed-article:9398632 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:9398632 | pubmed:meshHeading | pubmed-meshheading:9398632-... | lld:pubmed |
| pubmed-article:9398632 | pubmed:meshHeading | pubmed-meshheading:9398632-... | lld:pubmed |
| pubmed-article:9398632 | pubmed:meshHeading | pubmed-meshheading:9398632-... | lld:pubmed |
| pubmed-article:9398632 | pubmed:meshHeading | pubmed-meshheading:9398632-... | lld:pubmed |
| pubmed-article:9398632 | pubmed:meshHeading | pubmed-meshheading:9398632-... | lld:pubmed |
| pubmed-article:9398632 | pubmed:meshHeading | pubmed-meshheading:9398632-... | lld:pubmed |
| pubmed-article:9398632 | pubmed:meshHeading | pubmed-meshheading:9398632-... | lld:pubmed |
| pubmed-article:9398632 | pubmed:meshHeading | pubmed-meshheading:9398632-... | lld:pubmed |
| pubmed-article:9398632 | pubmed:meshHeading | pubmed-meshheading:9398632-... | lld:pubmed |
| pubmed-article:9398632 | pubmed:meshHeading | pubmed-meshheading:9398632-... | lld:pubmed |
| pubmed-article:9398632 | pubmed:meshHeading | pubmed-meshheading:9398632-... | lld:pubmed |
| pubmed-article:9398632 | pubmed:meshHeading | pubmed-meshheading:9398632-... | lld:pubmed |
| pubmed-article:9398632 | pubmed:meshHeading | pubmed-meshheading:9398632-... | lld:pubmed |
| pubmed-article:9398632 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9398632 | pubmed:articleTitle | Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants. | lld:pubmed |
| pubmed-article:9398632 | pubmed:affiliation | Department of Pathology, New York University Medical Center, New York 10016, USA. | lld:pubmed |
| pubmed-article:9398632 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9398632 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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