| pubmed-article:9395527 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9395527 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9395527 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:9395527 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9395527 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:9395527 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:9395527 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:9395527 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:9395527 | pubmed:issue | 50 | lld:pubmed |
| pubmed-article:9395527 | pubmed:dateCreated | 1998-1-15 | lld:pubmed |
| pubmed-article:9395527 | pubmed:abstractText | The CD5 receptor on T lymphocytes is involved in T cell activation and T-B cell interactions. In the present study, we have characterized the signaling pathways induced by anti-CD5 stimulation in human T lymphocytes. In T lymphocytes, anti-CD5 co-stimulation enhances the phytohemagglutinin/anti-CD28-induced interleukin-2 (IL-2) mRNA accumulation 1.6-fold and IL-2 protein secretion 2. 2-fold, whereby the up-regulation is mediated at both the transcriptional and post-transcriptional level. The CD5 signaling pathway up-regulates the IL-2 gene expression by increasing the DNA binding and transactivation activity of activator protein 1 but affects none of the other transcription factors like nuclear factor of activated T cells, nuclear factor kappaB, Oct, and CD28-responsive complex/nuclear factor of mitogen-activated T cells involved in the regulation of the IL-2 promoter activity. The CD5-induced increase of the activator protein 1 activity is mediated through the activation of calcium/calmodulin-dependent (CaM) kinase type IV, and is independent of the activation of mitogen-activated protein kinases Jun N-terminal kinase, extracellular signal-regulated kinase, and p38/Mpk2, and calcium/calmodul-independent kinase type II. The expression of a dominant negative mutant of CaM kinase IV in T lymphocytes transfected with an IL-2 promoter-driven reporter construct completely abrogates the response to CD5 stimulation, indicating that CaM kinase IV is essential to the CD5 signaling pathway. In addition, it is demonstrated that calcium/calmodulin-dependent kinase type IV is also involved in the stabilization of the IL-2 transcripts, which is observed after co-stimulation of phytohemagglutinin/anti-CD28 activated T lymphocytes with anti-CD5. | lld:pubmed |
| pubmed-article:9395527 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9395527 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9395527 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9395527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9395527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9395527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9395527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9395527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9395527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9395527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9395527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9395527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9395527 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9395527 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9395527 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9395527 | pubmed:author | pubmed-author:VellengaEE | lld:pubmed |
| pubmed-article:9395527 | pubmed:author | pubmed-author:TokumitsuHH | lld:pubmed |
| pubmed-article:9395527 | pubmed:author | pubmed-author:de LeijL FLF | lld:pubmed |
| pubmed-article:9395527 | pubmed:author | pubmed-author:WaymanG AGA | lld:pubmed |
| pubmed-article:9395527 | pubmed:author | pubmed-author:GringhuisS... | lld:pubmed |
| pubmed-article:9395527 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9395527 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:9395527 | pubmed:volume | 272 | lld:pubmed |
| pubmed-article:9395527 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9395527 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9395527 | pubmed:pagination | 31809-20 | lld:pubmed |
| pubmed-article:9395527 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:9395527 | pubmed:meshHeading | pubmed-meshheading:9395527-... | lld:pubmed |
| pubmed-article:9395527 | pubmed:meshHeading | pubmed-meshheading:9395527-... | lld:pubmed |
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| pubmed-article:9395527 | pubmed:meshHeading | pubmed-meshheading:9395527-... | lld:pubmed |
| pubmed-article:9395527 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9395527 | pubmed:articleTitle | The Ca2+/calmodulin-dependent kinase type IV is involved in the CD5-mediated signaling pathway in human T lymphocytes. | lld:pubmed |
| pubmed-article:9395527 | pubmed:affiliation | Division of Hematology, Department of Internal Medicine, University of Groningen, 9713 GZ Groningen, The Netherlands. | lld:pubmed |
| pubmed-article:9395527 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9395527 | pubmed:publicationType | In Vitro | lld:pubmed |
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