| pubmed-article:9393854 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9393854 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9393854 | lifeskim:mentions | umls-concept:C0027573 | lld:lifeskim |
| pubmed-article:9393854 | lifeskim:mentions | umls-concept:C0599122 | lld:lifeskim |
| pubmed-article:9393854 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:9393854 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
| pubmed-article:9393854 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
| pubmed-article:9393854 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
| pubmed-article:9393854 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9393854 | pubmed:dateCreated | 1997-12-29 | lld:pubmed |
| pubmed-article:9393854 | pubmed:abstractText | Invasion of human mucosal cells by N. gonorrhoeae via the binding to heparansulfate proteoglycan receptors is considered a crucial event of the infection. Using different human epithelial cells and primary fibroblasts, we show here an activation of the phosphatidylcholine-specific phospholipase C (PC-PLC) and acidic sphingomyelinase (ASM) by N. gonorrhoeae, resulting in the release of diacylglycerol and ceramide. Genetic and/or pharmacological blockade of ASM and PC-PLC cause inhibition of cellular invasion by N. gonorrhoeae. Complementation of ASM-deficient fibroblasts from Niemann-Pick disease patients restored N. gonorrhoeae-induced signaling and entry processes. The activation of PC-PLC and ASM, therefore, is an essential requirement for the entry of N. gonorrhoeae into distinct nonphagocytic human cell types including several epithelial cells and primary fibroblasts. | lld:pubmed |
| pubmed-article:9393854 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9393854 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9393854 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9393854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9393854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9393854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9393854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9393854 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9393854 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9393854 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9393854 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:9393854 | pubmed:author | pubmed-author:HarzerKK | lld:pubmed |
| pubmed-article:9393854 | pubmed:author | pubmed-author:LaneDD | lld:pubmed |
| pubmed-article:9393854 | pubmed:author | pubmed-author:SandhoffKK | lld:pubmed |
| pubmed-article:9393854 | pubmed:author | pubmed-author:BrennerBB | lld:pubmed |
| pubmed-article:9393854 | pubmed:author | pubmed-author:MeyerT FTF | lld:pubmed |
| pubmed-article:9393854 | pubmed:author | pubmed-author:GulbinsEE | lld:pubmed |
| pubmed-article:9393854 | pubmed:author | pubmed-author:FerlinzKK | lld:pubmed |
| pubmed-article:9393854 | pubmed:author | pubmed-author:GrassméHH | lld:pubmed |
| pubmed-article:9393854 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9393854 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:9393854 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:9393854 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9393854 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9393854 | pubmed:pagination | 605-15 | lld:pubmed |
| pubmed-article:9393854 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:meshHeading | pubmed-meshheading:9393854-... | lld:pubmed |
| pubmed-article:9393854 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9393854 | pubmed:articleTitle | Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells. | lld:pubmed |
| pubmed-article:9393854 | pubmed:affiliation | Max-Planck-Institut für Biologie, Abteilung Infektionsbiologie, Tübingen, Germany. | lld:pubmed |
| pubmed-article:9393854 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9393854 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9393854 | lld:pubmed |
