| pubmed-article:9392498 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9392498 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:9392498 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:9392498 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:9392498 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:9392498 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:9392498 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9392498 | pubmed:dateCreated | 1997-12-23 | lld:pubmed |
| pubmed-article:9392498 | pubmed:abstractText | A modified platelet response to aggregating stimuli is supposed to play a role in the pathogenesis of diabetic macroangiopathy. We studied the fluidity and microheterogeneity of the external surface of the platelet membrane and the activities of the plasma membrane Na+-K+-ATPase and Ca2+-ATPase in 21 men with type 1 diabetes and in 20 control subjects before and after in vitro thrombin addition. In the resting state, platelets from type 1 diabetic patients showed an increased fluidity and microheterogeneity of the platelet membrane, a higher Ca2+-ATPase activity, and a reduced Na+-K+-ATPase activity in comparison with platelets from healthy subjects. The fatty acid composition was also modified, with increased C 16:1 and decreased C 18:0 content. Control cells incubated with thrombin showed a modification of the membrane parameters opposite to the response observed in type 1 cells after the stimulation. The incubation of control platelets in the resting state with high concentrations of glucose modified the fluidity of the plasma membrane Na+-K+-ATPase and Ca2+-ATPase activities in an opposite way in comparison with the alterations observed in type 1 platelets. This study suggests that in type 1 diabetic patients, the platelet membrane responds to activation with a molecular remodeling different from the response of healthy subjects. The abnormal organization of the membrane might contribute to the altered platelet functions in type 1 diabetic patients, but acute exposure to high glucose levels does not seem able to modify the platelet membrane in the way observed in type 1 diabetes. | lld:pubmed |
| pubmed-article:9392498 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9392498 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9392498 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9392498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9392498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9392498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9392498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9392498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9392498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9392498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9392498 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9392498 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9392498 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:9392498 | pubmed:author | pubmed-author:MazzantiLL | lld:pubmed |
| pubmed-article:9392498 | pubmed:author | pubmed-author:CuratolaGG | lld:pubmed |
| pubmed-article:9392498 | pubmed:author | pubmed-author:RabiniR ARA | lld:pubmed |
| pubmed-article:9392498 | pubmed:author | pubmed-author:StaffolaniRR | lld:pubmed |
| pubmed-article:9392498 | pubmed:author | pubmed-author:FumelliPP | lld:pubmed |
| pubmed-article:9392498 | pubmed:author | pubmed-author:MartarelliDD | lld:pubmed |
| pubmed-article:9392498 | pubmed:author | pubmed-author:SalvoliniEE | lld:pubmed |
| pubmed-article:9392498 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9392498 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:9392498 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9392498 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9392498 | pubmed:pagination | 2069-74 | lld:pubmed |
| pubmed-article:9392498 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:9392498 | pubmed:meshHeading | pubmed-meshheading:9392498-... | lld:pubmed |
| pubmed-article:9392498 | pubmed:meshHeading | pubmed-meshheading:9392498-... | lld:pubmed |
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| pubmed-article:9392498 | pubmed:meshHeading | pubmed-meshheading:9392498-... | lld:pubmed |
| pubmed-article:9392498 | pubmed:meshHeading | pubmed-meshheading:9392498-... | lld:pubmed |
| pubmed-article:9392498 | pubmed:meshHeading | pubmed-meshheading:9392498-... | lld:pubmed |
| pubmed-article:9392498 | pubmed:meshHeading | pubmed-meshheading:9392498-... | lld:pubmed |
| pubmed-article:9392498 | pubmed:meshHeading | pubmed-meshheading:9392498-... | lld:pubmed |
| pubmed-article:9392498 | pubmed:meshHeading | pubmed-meshheading:9392498-... | lld:pubmed |
| pubmed-article:9392498 | pubmed:meshHeading | pubmed-meshheading:9392498-... | lld:pubmed |
| pubmed-article:9392498 | pubmed:meshHeading | pubmed-meshheading:9392498-... | lld:pubmed |
| pubmed-article:9392498 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9392498 | pubmed:articleTitle | Altered platelet membrane dynamic properties in type 1 diabetes. | lld:pubmed |
| pubmed-article:9392498 | pubmed:affiliation | Institute of Biochemistry, University of Ancona, INRCA, Italy. mazzanti@popcsi.unian.it | lld:pubmed |
| pubmed-article:9392498 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9392498 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
