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pubmed-article:9392357pubmed:abstractTextA 57-year-old female was admitted to our hospital because of Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). On admission, disturbance of consciousness and hyponatremia were recognized. The patient's endocrinological data showed low levels of adrenocorticotropic hormone (ACTH) (less than 5 pg/ml) and cortisol (5.9 microg/dl). Other anterior pituitary hormones were normal. Plasma ACTH and cortisol did not respond to the corticotropin releasing factor (CRF) test. A diagnosis of isolated ACTH deficiency was made. This is a rare case of isolated ACTH deficiency complicated with hematological malignancies.lld:pubmed
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pubmed-article:9392357pubmed:articleTitleAcute lymphoblastic leukemia with isolated adrenocorticotropic hormone deficiency.lld:pubmed
pubmed-article:9392357pubmed:affiliationDepartment of Internal Medicine, Nippon Medical School, Sendagi, Tokyo.lld:pubmed
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