| pubmed-article:9391128 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C1564874 | lld:lifeskim |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C0025933 | lld:lifeskim |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C0299583 | lld:lifeskim |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C0011847 | lld:lifeskim |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C1947976 | lld:lifeskim |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C0021492 | lld:lifeskim |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:9391128 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:9391128 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:9391128 | pubmed:dateCreated | 1998-1-15 | lld:pubmed |
| pubmed-article:9391128 | pubmed:abstractText | The ob/ob mouse is genetically deficient in leptin and exhibits a phenotype that includes obesity and non-insulin-dependent diabetes mellitus. This phenotype closely resembles the morbid obesity seen in humans. In this study, we demonstrate that a single intramuscular injection of a recombinant adeno-associated virus (AAV) vector encoding mouse leptin (rAAV-leptin) in ob/ob mice leads to prevention of obesity and diabetes. The treated animals show normalization of metabolic abnormalities including hyperglycemia, insulin resistance, impaired glucose tolerance, and lethargy. The effects of a single injection have lasted through the 6-month course of the study. At all time points measured the circulating levels of leptin in the serum were similar to age-matched control C57 mice. These results demonstrate that maintenance of normal levels of leptin (2-5 ng/ml) in the circulation can prevent both the onset of obesity and associated non-insulin-dependent diabetes. Thus a single injection of a rAAV vector expressing a therapeutic gene can lead to complete and long-term correction of a genetic disorder. Our study demonstrates the long-term correction of a disease caused by a genetic defect and proves the feasibility of using rAAV-based vectors for the treatment of chronic disorders like obesity. | lld:pubmed |
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| pubmed-article:9391128 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9391128 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9391128 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9391128 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9391128 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9391128 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9391128 | pubmed:author | pubmed-author:WilliamsL TLT | lld:pubmed |
| pubmed-article:9391128 | pubmed:author | pubmed-author:GieseKK | lld:pubmed |
| pubmed-article:9391128 | pubmed:author | pubmed-author:MurphyJ EJE | lld:pubmed |
| pubmed-article:9391128 | pubmed:author | pubmed-author:ZhouSS | lld:pubmed |
| pubmed-article:9391128 | pubmed:author | pubmed-author:DwarkiV JVJ | lld:pubmed |
| pubmed-article:9391128 | pubmed:author | pubmed-author:EscobedoJ AJA | lld:pubmed |
| pubmed-article:9391128 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9391128 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:9391128 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:9391128 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9391128 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9391128 | pubmed:pagination | 13921-6 | lld:pubmed |
| pubmed-article:9391128 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:9391128 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9391128 | pubmed:articleTitle | Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin. | lld:pubmed |
| pubmed-article:9391128 | pubmed:affiliation | Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608, USA. | lld:pubmed |
| pubmed-article:9391128 | pubmed:publicationType | Journal Article | lld:pubmed |
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