| pubmed-article:9390559 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9390559 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
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| pubmed-article:9390559 | lifeskim:mentions | umls-concept:C0016163 | lld:lifeskim |
| pubmed-article:9390559 | lifeskim:mentions | umls-concept:C0424522 | lld:lifeskim |
| pubmed-article:9390559 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:9390559 | lifeskim:mentions | umls-concept:C0040674 | lld:lifeskim |
| pubmed-article:9390559 | lifeskim:mentions | umls-concept:C0600401 | lld:lifeskim |
| pubmed-article:9390559 | lifeskim:mentions | umls-concept:C0524865 | lld:lifeskim |
| pubmed-article:9390559 | lifeskim:mentions | umls-concept:C0004898 | lld:lifeskim |
| pubmed-article:9390559 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9390559 | pubmed:dateCreated | 1997-12-23 | lld:pubmed |
| pubmed-article:9390559 | pubmed:abstractText | Members of the Tc1/mariner superfamily of transposons isolated from fish appear to be transpositionally inactive due to the accumulation of mutations. Molecular phylogenetic data were used to construct a synthetic transposon, Sleeping Beauty, which could be identical or equivalent to an ancient element that dispersed in fish genomes in part by horizontal transmission between species. A consensus sequence of a transposase gene of the salmonid subfamily of elements was engineered by eliminating the inactivating mutations. Sleeping Beauty transposase binds to the inverted repeats of salmonid transposons in a substrate-specific manner, and it mediates precise cut-and-paste transposition in fish as well as in mouse and human cells. Sleeping Beauty is an active DNA-transposon system from vertebrates for genetic transformation and insertional mutagenesis. | lld:pubmed |
| pubmed-article:9390559 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9390559 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9390559 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9390559 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9390559 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9390559 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9390559 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:9390559 | pubmed:author | pubmed-author:HackettP BPB | lld:pubmed |
| pubmed-article:9390559 | pubmed:author | pubmed-author:IzsvákZZ | lld:pubmed |
| pubmed-article:9390559 | pubmed:author | pubmed-author:IvicsZZ | lld:pubmed |
| pubmed-article:9390559 | pubmed:author | pubmed-author:PlasterkR HRH | lld:pubmed |
| pubmed-article:9390559 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9390559 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:9390559 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:9390559 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9390559 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9390559 | pubmed:pagination | 501-10 | lld:pubmed |
| pubmed-article:9390559 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9390559 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9390559 | pubmed:articleTitle | Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. | lld:pubmed |
| pubmed-article:9390559 | pubmed:affiliation | Department of Genetics and Cell Biology, University of Minnesota, St. Paul 55108-1095, USA. | lld:pubmed |
| pubmed-article:9390559 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9390559 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9390559 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9390559 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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