| pubmed-article:9389257 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9389257 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9389257 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:9389257 | lifeskim:mentions | umls-concept:C0038317 | lld:lifeskim |
| pubmed-article:9389257 | lifeskim:mentions | umls-concept:C0043047 | lld:lifeskim |
| pubmed-article:9389257 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:9389257 | lifeskim:mentions | umls-concept:C0002932 | lld:lifeskim |
| pubmed-article:9389257 | lifeskim:mentions | umls-concept:C0668283 | lld:lifeskim |
| pubmed-article:9389257 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9389257 | pubmed:dateCreated | 1997-12-17 | lld:pubmed |
| pubmed-article:9389257 | pubmed:abstractText | Ten male volunteers received a 1-min i.v. infusion of a new water soluble steroid anaesthetic agent, ORG 21465. Individuals received doses ranging from 0.8 to 1.8 mg kg-1. All subjects experienced venous pain at the site of injection; those receiving 1.0 mg kg-1 or more became anaesthetized. There was no evidence of histamine release and apnoea did not occur. Excitatory phenomena were observed in all subjects and were dose related; no spikes were seen on the EEG. Pharmacokinetic analysis supported a three-compartment (non-weight-related) model with compartmental volumes V1, V2 and V3 of 4.31, 14.2 and 89.4 litre, respectively. Clearance from the central compartment V1 was 1.55 litre min-1. Inter-compartmental clearances Q1 and Q2 were 2.54 and 1.79 litre min-1. We found that ORG 21465 was an effective anaesthetic in humans. The relationship between sedation, anaesthesia and excitation requires further exploration. | lld:pubmed |
| pubmed-article:9389257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9389257 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9389257 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9389257 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9389257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9389257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9389257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9389257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9389257 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9389257 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9389257 | pubmed:issn | 0007-0912 | lld:pubmed |
| pubmed-article:9389257 | pubmed:author | pubmed-author:ThompsonPP | lld:pubmed |
| pubmed-article:9389257 | pubmed:author | pubmed-author:WeidemanM MMM | lld:pubmed |
| pubmed-article:9389257 | pubmed:author | pubmed-author:AndrewsC JCJ | lld:pubmed |
| pubmed-article:9389257 | pubmed:author | pubmed-author:DaniellC JCJ | lld:pubmed |
| pubmed-article:9389257 | pubmed:author | pubmed-author:WrightP MPM | lld:pubmed |
| pubmed-article:9389257 | pubmed:author | pubmed-author:CrossMM | lld:pubmed |
| pubmed-article:9389257 | pubmed:author | pubmed-author:SneydJ RJR | lld:pubmed |
| pubmed-article:9389257 | pubmed:author | pubmed-author:VoortmanGG | lld:pubmed |
| pubmed-article:9389257 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9389257 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:9389257 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9389257 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9389257 | pubmed:pagination | 427-32 | lld:pubmed |
| pubmed-article:9389257 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9389257 | pubmed:meshHeading | pubmed-meshheading:9389257-... | lld:pubmed |
| pubmed-article:9389257 | pubmed:meshHeading | pubmed-meshheading:9389257-... | lld:pubmed |
| pubmed-article:9389257 | pubmed:meshHeading | pubmed-meshheading:9389257-... | lld:pubmed |
| pubmed-article:9389257 | pubmed:meshHeading | pubmed-meshheading:9389257-... | lld:pubmed |
| pubmed-article:9389257 | pubmed:meshHeading | pubmed-meshheading:9389257-... | lld:pubmed |
| pubmed-article:9389257 | pubmed:meshHeading | pubmed-meshheading:9389257-... | lld:pubmed |
| pubmed-article:9389257 | pubmed:meshHeading | pubmed-meshheading:9389257-... | lld:pubmed |
| pubmed-article:9389257 | pubmed:meshHeading | pubmed-meshheading:9389257-... | lld:pubmed |
| pubmed-article:9389257 | pubmed:meshHeading | pubmed-meshheading:9389257-... | lld:pubmed |
| pubmed-article:9389257 | pubmed:meshHeading | pubmed-meshheading:9389257-... | lld:pubmed |
| pubmed-article:9389257 | pubmed:meshHeading | pubmed-meshheading:9389257-... | lld:pubmed |
| pubmed-article:9389257 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9389257 | pubmed:articleTitle | Administration to humans of ORG 21465, a water soluble steroid i.v. anaesthetic agent. | lld:pubmed |
| pubmed-article:9389257 | pubmed:affiliation | Department of Anaesthesia, Derriford Hospital, Plymouth, UK. | lld:pubmed |
| pubmed-article:9389257 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9389257 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:9389257 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9389257 | lld:pubmed |
