| pubmed-article:9382917 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9382917 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:9382917 | lifeskim:mentions | umls-concept:C0009221 | lld:lifeskim |
| pubmed-article:9382917 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:9382917 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:9382917 | lifeskim:mentions | umls-concept:C1519068 | lld:lifeskim |
| pubmed-article:9382917 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9382917 | pubmed:dateCreated | 1998-1-15 | lld:pubmed |
| pubmed-article:9382917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9382917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9382917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9382917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9382917 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9382917 | pubmed:abstractText | One of the most common cattle major histocompatibility complex DRB3 alleles, *0201, includes a deletion of codon 65 encoding one residue in the alpha-helical chain. The mutation is functionally interesting and is likely to influence peptide binding. Exon 2 of two additional del65 alleles, *3301 and *4101, have now been sequenced with the aim to investigate the evolutionary relationship of this allelic group. Despite a fairly large genetic distance between the three alleles (11-17 nucleotide substitutions causing 8-11 amino acid substitutions) we found clear indications of a common ancestry. The alpha-helical region was very similar or identical among the alleles whereas the beta-strand region was quite divergent. The results indicated that interallelic recombination has contributed to the diversification of the del65 group. Deletion of codon 65 has also been found in a roe deer DRB1 allele and a cattle DQB3 allele. Sequence comparisons of the cattle and roe deer DRB del65 alleles refuted the possibility of a trans-species persistence of a del65 allelic lineage but the two species may share a short ancestral sequence motif including del65. In addition to del65, the cattle DQB3 allele did not show any striking sequence similarities to the DRB alleles. | lld:pubmed |
| pubmed-article:9382917 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9382917 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9382917 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9382917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9382917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9382917 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9382917 | pubmed:issn | 0093-7711 | lld:pubmed |
| pubmed-article:9382917 | pubmed:author | pubmed-author:AnderssonLL | lld:pubmed |
| pubmed-article:9382917 | pubmed:author | pubmed-author:LewinH AHA | lld:pubmed |
| pubmed-article:9382917 | pubmed:author | pubmed-author:MikkoSS | lld:pubmed |
| pubmed-article:9382917 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9382917 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:9382917 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9382917 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9382917 | pubmed:pagination | 23-9 | lld:pubmed |
| pubmed-article:9382917 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9382917 | pubmed:meshHeading | pubmed-meshheading:9382917-... | lld:pubmed |
| pubmed-article:9382917 | pubmed:meshHeading | pubmed-meshheading:9382917-... | lld:pubmed |
| pubmed-article:9382917 | pubmed:meshHeading | pubmed-meshheading:9382917-... | lld:pubmed |
| pubmed-article:9382917 | pubmed:meshHeading | pubmed-meshheading:9382917-... | lld:pubmed |
| pubmed-article:9382917 | pubmed:meshHeading | pubmed-meshheading:9382917-... | lld:pubmed |
| pubmed-article:9382917 | pubmed:meshHeading | pubmed-meshheading:9382917-... | lld:pubmed |
| pubmed-article:9382917 | pubmed:meshHeading | pubmed-meshheading:9382917-... | lld:pubmed |
| pubmed-article:9382917 | pubmed:meshHeading | pubmed-meshheading:9382917-... | lld:pubmed |
| pubmed-article:9382917 | pubmed:meshHeading | pubmed-meshheading:9382917-... | lld:pubmed |
| pubmed-article:9382917 | pubmed:meshHeading | pubmed-meshheading:9382917-... | lld:pubmed |
| pubmed-article:9382917 | pubmed:meshHeading | pubmed-meshheading:9382917-... | lld:pubmed |
| pubmed-article:9382917 | pubmed:meshHeading | pubmed-meshheading:9382917-... | lld:pubmed |
| pubmed-article:9382917 | pubmed:meshHeading | pubmed-meshheading:9382917-... | lld:pubmed |
| pubmed-article:9382917 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9382917 | pubmed:articleTitle | A phylogenetic analysis of cattle DRB3 alleles with a deletion of codon 65. | lld:pubmed |
| pubmed-article:9382917 | pubmed:affiliation | Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597, S-751 24 Uppsala, Sweden. | lld:pubmed |
| pubmed-article:9382917 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9382917 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
