| pubmed-article:9382844 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9382844 | lifeskim:mentions | umls-concept:C0007610 | lld:lifeskim |
| pubmed-article:9382844 | lifeskim:mentions | umls-concept:C0872014 | lld:lifeskim |
| pubmed-article:9382844 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:9382844 | lifeskim:mentions | umls-concept:C1521828 | lld:lifeskim |
| pubmed-article:9382844 | lifeskim:mentions | umls-concept:C1155589 | lld:lifeskim |
| pubmed-article:9382844 | lifeskim:mentions | umls-concept:C1704240 | lld:lifeskim |
| pubmed-article:9382844 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9382844 | pubmed:dateCreated | 1998-2-19 | lld:pubmed |
| pubmed-article:9382844 | pubmed:abstractText | A-kinase anchor protein 75 (AKAP75) binds regulatory subunits (RIIalpha and RIIbeta) of type II protein kinase A (PKAII) isoforms and targets the resulting complexes to sites in the cytoskeleton that abut the plasma membrane [1-7]. Co-localization of AKAP75-PKAII with adenylate cyclase and PKA substrate/effector proteins in cytoskeleton and plasma membrane effects a physical and functional integration of up-stream and downstream signaling proteins, thereby ensuring efficient propagation of signals carried by locally generated cyclic AMP (cAMP) [4-9]. An important, but previously untested, prediction of the AKAP model is that efficient, cyclic nucleotide-dependent liberation of diffusible PKA catalytic subunits from cytoskeleton-bound AKAP75-PKAII complexes will also enhance signaling to distal organelles, such as the nucleus. We tested this idea by suing HEK-A75 cells, in which PKAII isoforms are immobilized in cortical cytoskeleton by AKAP75. Abilities of HEK-A75 and control cells (with cytoplasmically dispersed PKAII isoforms) to respond to increases in cAMP content were compared. Cells with anchored PKAII exhibited a threefold higher level of nuclear catalytic subunit content and 4-10-fold greater increments in phosphorylation of a regulatory serine residue in cAMP response element binding protein (CREB) and in phosphoCREB-stimulated transcription of the c-fos gene. Each effect occurred more rapidly in cells containing targeted AKAP75-PKAII complexes. Thus, anchoring of PKAII in actin cortical cytoskeleton increases the rate, magnitude and sensitivity of cAMP signaling to the nucleus. | lld:pubmed |
| pubmed-article:9382844 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9382844 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9382844 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9382844 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9382844 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9382844 | pubmed:issn | 0960-9822 | lld:pubmed |
| pubmed-article:9382844 | pubmed:author | pubmed-author:LUMM | lld:pubmed |
| pubmed-article:9382844 | pubmed:author | pubmed-author:RubinC SCS | lld:pubmed |
| pubmed-article:9382844 | pubmed:author | pubmed-author:GottesmanM... | lld:pubmed |
| pubmed-article:9382844 | pubmed:author | pubmed-author:AvvedimentoE... | lld:pubmed |
| pubmed-article:9382844 | pubmed:author | pubmed-author:FelicielloAA | lld:pubmed |
| pubmed-article:9382844 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9382844 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9382844 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:9382844 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9382844 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9382844 | pubmed:pagination | 1011-4 | lld:pubmed |
| pubmed-article:9382844 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9382844 | pubmed:meshHeading | pubmed-meshheading:9382844-... | lld:pubmed |
| pubmed-article:9382844 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9382844 | pubmed:articleTitle | A-kinase anchor protein 75 increases the rate and magnitude of cAMP signaling to the nucleus. | lld:pubmed |
| pubmed-article:9382844 | pubmed:affiliation | Department of Molecular Pharmacology, Atran Laboratories, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA. | lld:pubmed |
| pubmed-article:9382844 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9382844 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9382844 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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