| pubmed-article:9379433 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9379433 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:9379433 | lifeskim:mentions | umls-concept:C0023175 | lld:lifeskim |
| pubmed-article:9379433 | lifeskim:mentions | umls-concept:C1148673 | lld:lifeskim |
| pubmed-article:9379433 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:9379433 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:9379433 | lifeskim:mentions | umls-concept:C0527260 | lld:lifeskim |
| pubmed-article:9379433 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:9379433 | pubmed:dateCreated | 1997-11-10 | lld:pubmed |
| pubmed-article:9379433 | pubmed:abstractText | The E2 protein is required for the replication of human papillomaviruses (HPVs), which are responsible for anogenital warts and cervical carcinomas. Using an NMR-based screen, we tested compounds for binding to the DNA-binding domain of the HPV-E2 protein. Three classes of compounds were identified which bound to two distinct sites on the protein. Biphenyl and biphenyl ether compounds containing a carboxylic acid bind to a site near the DNA recognition helix and inhibit the binding of E2 to DNA. Benzophenone-containing compounds which lack a carboxylic acid group bind to the beta-barrel formed by the dimer interface and exhibit negligible effects on the binding of E2 to DNA. Structure-activity relationships from the biphenyl and biphenyl ether compounds were combined to produce a compound [5-(3'-(3",5"-dichlorophenoxy)-phenyl)-2,4-pentadienoic acid] with an IC50 value of approximately 10 microM. This compound represents a useful lead for the development of antiviral agents that interfere with HPV replication and further illustrates the usefulness of the SAR by NMR method in the drug discovery process. | lld:pubmed |
| pubmed-article:9379433 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9379433 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9379433 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9379433 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9379433 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9379433 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9379433 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:9379433 | pubmed:author | pubmed-author:EganD ADA | lld:pubmed |
| pubmed-article:9379433 | pubmed:author | pubmed-author:FesikS WSW | lld:pubmed |
| pubmed-article:9379433 | pubmed:author | pubmed-author:MiddletonTT | lld:pubmed |
| pubmed-article:9379433 | pubmed:author | pubmed-author:HolzmanT FTF | lld:pubmed |
| pubmed-article:9379433 | pubmed:author | pubmed-author:WalterK AKA | lld:pubmed |
| pubmed-article:9379433 | pubmed:author | pubmed-author:KempfD JDJ | lld:pubmed |
| pubmed-article:9379433 | pubmed:author | pubmed-author:RobinsT STS | lld:pubmed |
| pubmed-article:9379433 | pubmed:author | pubmed-author:HajdukP JPJ | lld:pubmed |
| pubmed-article:9379433 | pubmed:author | pubmed-author:ShukerS BSB | lld:pubmed |
| pubmed-article:9379433 | pubmed:author | pubmed-author:DingerMM | lld:pubmed |
| pubmed-article:9379433 | pubmed:author | pubmed-author:MiknisG FGF | lld:pubmed |
| pubmed-article:9379433 | pubmed:author | pubmed-author:MerlockMM | lld:pubmed |
| pubmed-article:9379433 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9379433 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:9379433 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:9379433 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9379433 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9379433 | pubmed:pagination | 3144-50 | lld:pubmed |
| pubmed-article:9379433 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9379433 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9379433 | pubmed:articleTitle | NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein. | lld:pubmed |
| pubmed-article:9379433 | pubmed:affiliation | Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064-3500, USA. | lld:pubmed |
| pubmed-article:9379433 | pubmed:publicationType | Journal Article | lld:pubmed |
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