| pubmed-article:9378980 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9378980 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:9378980 | lifeskim:mentions | umls-concept:C0003947 | lld:lifeskim |
| pubmed-article:9378980 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9378980 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:9378980 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:9378980 | lifeskim:mentions | umls-concept:C0162772 | lld:lifeskim |
| pubmed-article:9378980 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:9378980 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9378980 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9378980 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:9378980 | pubmed:dateCreated | 1997-11-7 | lld:pubmed |
| pubmed-article:9378980 | pubmed:abstractText | IL-6 has been characterized as a pleiotropic cytokine with multiple biologic activities, but its induction and role in asbestos diseases have not been studied. Asbestos fibers were found to stimulate IL-6 expression and secretion in pulmonary type II-like epithelial A549 cells as well as in normal human bronchial epithelial cells. IL-6 induction was dependent on the intracellular redox-oxidative state, since intracellular hydroxyl scavengers and N-acetylcysteine, a precursor of glutathione, abrogated IL-6 secretion by asbestos or H2O2. IL-6 induction paralleled increased DNA binding activity to the nuclear factor-kappa B (NF-kappa B)- and NF-IL-6-recognized sites in the IL-6 promoter. The NF-kappa B and NF-IL-6 DNA binding proteins were immunochemically characterized as a heterodimer p65/p50 and a homodimer C/EBP beta, respectively. Stimulation of DNA binding activity to the NF-kappa B and NF-IL-6 binding sites of the IL-6 promoter by asbestos or H2O2 were inhibited by tetramethylthiourea, a hydroxyl radical scavenger. The role of local IL-6 production in the pathophysiologic processes of fiber-induced lung disorders was examined. Although less active than fibroblast growth factor, human rIL-6 also stimulated lung fibroblast growth, as evidenced by increased [3H]thymidine incorporation. Furthermore, elevated IL-6 levels were found in bronchoalveolar lavage fluids from patients diagnosed with lung fibrosis and work-related histories of long term asbestos exposure. Taken together, the results suggest that asbestos-induced oxidative stress is involved in the activation of NF-kappa B and NF-IL-6 transcription factors, which recognize the IL-6 promoter. The resulting increase in IL-6 expression may be involved in both inflammatory and fibrotic processes in the lung. | lld:pubmed |
| pubmed-article:9378980 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9378980 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9378980 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9378980 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9378980 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9378980 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9378980 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9378980 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9378980 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9378980 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9378980 | pubmed:author | pubmed-author:LusterM IMI | lld:pubmed |
| pubmed-article:9378980 | pubmed:author | pubmed-author:KommineniCC | lld:pubmed |
| pubmed-article:9378980 | pubmed:author | pubmed-author:MunsonA EAE | lld:pubmed |
| pubmed-article:9378980 | pubmed:author | pubmed-author:YuII | lld:pubmed |
| pubmed-article:9378980 | pubmed:author | pubmed-author:ToriumiWW | lld:pubmed |
| pubmed-article:9378980 | pubmed:author | pubmed-author:SimeonovaP... | lld:pubmed |
| pubmed-article:9378980 | pubmed:author | pubmed-author:ErkanMM | lld:pubmed |
| pubmed-article:9378980 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9378980 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9378980 | pubmed:volume | 159 | lld:pubmed |
| pubmed-article:9378980 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9378980 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9378980 | pubmed:pagination | 3921-8 | lld:pubmed |
| pubmed-article:9378980 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:meshHeading | pubmed-meshheading:9378980-... | lld:pubmed |
| pubmed-article:9378980 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9378980 | pubmed:articleTitle | Molecular regulation of IL-6 activation by asbestos in lung epithelial cells: role of reactive oxygen species. | lld:pubmed |
| pubmed-article:9378980 | pubmed:affiliation | Toxicology and Molecular Biology Branch, National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA. | lld:pubmed |
| pubmed-article:9378980 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9378980 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9378980 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9378980 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9378980 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9378980 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9378980 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9378980 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9378980 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9378980 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9378980 | lld:pubmed |
