| pubmed-article:9378959 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9378959 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:9378959 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:9378959 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:9378959 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:9378959 | lifeskim:mentions | umls-concept:C0205615 | lld:lifeskim |
| pubmed-article:9378959 | lifeskim:mentions | umls-concept:C1819440 | lld:lifeskim |
| pubmed-article:9378959 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:9378959 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:9378959 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:9378959 | pubmed:dateCreated | 1997-11-7 | lld:pubmed |
| pubmed-article:9378959 | pubmed:abstractText | CD4+ T cell differentiation into cells capable of producing IL-4 and IL-13 (Th2 cells) requires the presence of IL-4 and is STAT-6 dependent. Here we show that IL-4 is not required for IL-4 or IL-13 production by Th2 cells. Anti-IL-4 or anti-IL-4R Ab did not diminish IL-4 production by Th2 cells in response to TCR-mediated stimulation, nor did IL-4 enhance IL-4 production in response to stimulation of Th2 cells with limiting amounts of Ag. Th2 cells prepared from IL-4 knockout mice were capable of producing IL-13 mRNA in response to stimulation with immobilized anti-CD3. IL-4 did not increase IL-13 mRNA expression. Despite the failure of IL-4 to effect IL-4 production by primed Th2 cells, a STAT-6 binding element was demonstrated in the IL-4 promoter. The authenticity of this element was demonstrated by oligonucleotide competition, by supershifting with anti-STAT-6 Ab, and by IL-4-inducible effects on transcription of a reporter gene under the control of a multimerized element fused to an IL-4 minimal promoter. Nonetheless, an IL-4 promoter construct lacking the STAT-6 binding element was as effective as a construct containing this element in anti-CD3-induced reporter transcription. Thus, this element, if biologically active, must function at a step in T cell responsiveness distinct from the acute production of IL-4 by Th2 cells in response to Ag or anti-CD3. | lld:pubmed |
| pubmed-article:9378959 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9378959 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9378959 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:9378959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9378959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9378959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9378959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9378959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9378959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9378959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9378959 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9378959 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9378959 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9378959 | pubmed:author | pubmed-author:PaulW EWE | lld:pubmed |
| pubmed-article:9378959 | pubmed:author | pubmed-author:Ben-SassonS... | lld:pubmed |
| pubmed-article:9378959 | pubmed:author | pubmed-author:HuangHH | lld:pubmed |
| pubmed-article:9378959 | pubmed:author | pubmed-author:ChenHH | lld:pubmed |
| pubmed-article:9378959 | pubmed:author | pubmed-author:Hu-LiJJ | lld:pubmed |
| pubmed-article:9378959 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9378959 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9378959 | pubmed:volume | 159 | lld:pubmed |
| pubmed-article:9378959 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9378959 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9378959 | pubmed:pagination | 3731-8 | lld:pubmed |
| pubmed-article:9378959 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:9378959 | pubmed:meshHeading | pubmed-meshheading:9378959-... | lld:pubmed |
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| pubmed-article:9378959 | pubmed:meshHeading | pubmed-meshheading:9378959-... | lld:pubmed |
| pubmed-article:9378959 | pubmed:meshHeading | pubmed-meshheading:9378959-... | lld:pubmed |
| pubmed-article:9378959 | pubmed:meshHeading | pubmed-meshheading:9378959-... | lld:pubmed |
| pubmed-article:9378959 | pubmed:meshHeading | pubmed-meshheading:9378959-... | lld:pubmed |
| pubmed-article:9378959 | pubmed:meshHeading | pubmed-meshheading:9378959-... | lld:pubmed |
| pubmed-article:9378959 | pubmed:meshHeading | pubmed-meshheading:9378959-... | lld:pubmed |
| pubmed-article:9378959 | pubmed:meshHeading | pubmed-meshheading:9378959-... | lld:pubmed |
| pubmed-article:9378959 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9378959 | pubmed:articleTitle | IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent. | lld:pubmed |
| pubmed-article:9378959 | pubmed:affiliation | Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-1892, USA. | lld:pubmed |
| pubmed-article:9378959 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9378959 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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