| pubmed-article:9377564 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9377564 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:9377564 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:9377564 | lifeskim:mentions | umls-concept:C0450429 | lld:lifeskim |
| pubmed-article:9377564 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:9377564 | lifeskim:mentions | umls-concept:C0241889 | lld:lifeskim |
| pubmed-article:9377564 | lifeskim:mentions | umls-concept:C0920269 | lld:lifeskim |
| pubmed-article:9377564 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:9377564 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:9377564 | pubmed:dateCreated | 1997-11-10 | lld:pubmed |
| pubmed-article:9377564 | pubmed:abstractText | We studied the presence of microsatellite instability (MSI) in a series of 108 gastric cancers (GCs) previously identified in an epidemiological study carried out in a high-risk area around Florence. To investigate associations between MSI and GC family history, 34 cases (31.5%) who had a GC-affected first-degree relative were included in the series. A family history positive for colorectal cancer was reported quite rarely (5.6%). The analysis of 6 microsatellite loci in DNA from paired normal tissue and tumor samples microdissected from paraffin-embedded specimens revealed varying degrees of instability: 56 cases (51.8%) did not show instability at any of the 6 loci; 19 (17.6%) showed instability at 1 locus; 16 (14.8%) showed instability at 2 loci; 11 (10.2%) showed instability at 3 loci; 4 (3.7%) showed instability at 4 loci; and 2 (1.9%) showed instability at 5 loci. The replication error-positive (RER+) phenotype, defined as the presence of MSI at 2 or more loci, had a frequency of 30.6% (33 of 108) and tended to be positively associated with female sex, intestinal histological type, advanced tumor stage, vascular invasion, positive GC family history, and blood group of A type. No correlation emerged between age at diagnosis and RER+ phenotype, whereas a significant association with the RER+ phenotype was shown by the antral location. A multivariate analysis adjusting for a selected group of potential confounding factors confirmed the strong association of the RER+ phenotype with the antral location (P = 0.001) and with a positive GC family history (P < 0.05). Survival analyses at 5 and 8 years showed no difference between RER+ and RER- patients, even when corrected for stage distribution. By the microdissection technique, we also used microsatellite allele patterns to investigate intratumoral heterogeneity and genetic relationships between tumors and adjacent dysplasia and/or intestinal metaplasia. Areas of metaplasia and dysplasia demonstrated MSI only in cases with MSI-positive tumors. In MSI-positive tumors, there was consistent evidence of intratumoral microsatellite allele heterogeneity, indicating the presence of genetically divergent tumor cell clones within the same neoplasm. | lld:pubmed |
| pubmed-article:9377564 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9377564 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9377564 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9377564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9377564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9377564 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9377564 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9377564 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9377564 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:9377564 | pubmed:author | pubmed-author:CamaAA | lld:pubmed |
| pubmed-article:9377564 | pubmed:author | pubmed-author:CalzolariAA | lld:pubmed |
| pubmed-article:9377564 | pubmed:author | pubmed-author:D'AmicoCC | lld:pubmed |
| pubmed-article:9377564 | pubmed:author | pubmed-author:MasalaGG | lld:pubmed |
| pubmed-article:9377564 | pubmed:author | pubmed-author:Mariani-Costa... | lld:pubmed |
| pubmed-article:9377564 | pubmed:author | pubmed-author:PallaLL | lld:pubmed |
| pubmed-article:9377564 | pubmed:author | pubmed-author:AmorosiAA | lld:pubmed |
| pubmed-article:9377564 | pubmed:author | pubmed-author:OttingJJ | lld:pubmed |
| pubmed-article:9377564 | pubmed:author | pubmed-author:FalchettiMM | lld:pubmed |
| pubmed-article:9377564 | pubmed:author | pubmed-author:De MarchisLL | lld:pubmed |
| pubmed-article:9377564 | pubmed:author | pubmed-author:SaievaCC | lld:pubmed |
| pubmed-article:9377564 | pubmed:author | pubmed-author:CimoliFF | lld:pubmed |
| pubmed-article:9377564 | pubmed:author | pubmed-author:TatarelliCC | lld:pubmed |
| pubmed-article:9377564 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9377564 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9377564 | pubmed:volume | 57 | lld:pubmed |
| pubmed-article:9377564 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9377564 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9377564 | pubmed:pagination | 4523-9 | lld:pubmed |
| pubmed-article:9377564 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:meshHeading | pubmed-meshheading:9377564-... | lld:pubmed |
| pubmed-article:9377564 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9377564 | pubmed:articleTitle | Microsatellite instability in gastric cancer is associated with tumor location and family history in a high-risk population from Tuscany. | lld:pubmed |
| pubmed-article:9377564 | pubmed:affiliation | Department of Oncology and Neurosciences, University Gabriele D'Annunzio, Chieti, Italy. | lld:pubmed |
| pubmed-article:9377564 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9377564 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9377564 | lld:pubmed |
