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pubmed-article:9377098pubmed:abstractTextEster analogues of methyl-2-(4-(2-piperidinoethoxy)benzoyl)-benzoate hydrochloride (pitofenone) (2) were prepared with an aim to find a more potent and metabolically stable antispasmodic compound. The compounds were evaluated for their in vitro and in vivo antispasmodic activity, and stability to in vitro enzymatic hydrolysis. Of the compounds synthesised, HL 752 (21) showed the most potent and long-lasting antispasmodic activity and was selected as the candidate for clinical development.lld:pubmed
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pubmed-article:9377098pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:9377098pubmed:year1997lld:pubmed
pubmed-article:9377098pubmed:articleTitleHL 752: a potent and long-acting antispasmodic agent.lld:pubmed
pubmed-article:9377098pubmed:affiliationResearch Centre, Hoechst Marion Roussel Limited, L.B.S. Marg, Mulund, Bombay, India.lld:pubmed
pubmed-article:9377098pubmed:publicationTypeJournal Articlelld:pubmed
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