| pubmed-article:9374187 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9374187 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:9374187 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:9374187 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:9374187 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:9374187 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:9374187 | lifeskim:mentions | umls-concept:C0521329 | lld:lifeskim |
| pubmed-article:9374187 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:9374187 | lifeskim:mentions | umls-concept:C0016904 | lld:lifeskim |
| pubmed-article:9374187 | lifeskim:mentions | umls-concept:C0061605 | lld:lifeskim |
| pubmed-article:9374187 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:9374187 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:9374187 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9374187 | pubmed:dateCreated | 1997-12-23 | lld:pubmed |
| pubmed-article:9374187 | pubmed:abstractText | Using patch-clamp techniques we studied several aspects of intracellular GABA(A) and glycine Cl- current regulation in cortical and spinal cord neurons, respectively. Activation of PKA with a permeable analog of cyclic AMP (cAMP) produced a potentiation of the Cl- current activated with glycine, but not of the current induced with GABA. The inactive analog was without effect. Activation of PKC with 1 microM PMA reduced the amplitude of the GABA(A) and glycine currents. Internal application of 1 mM cGMP, on the other hand, had no effect on the amplitude of either current. The amplitude of these inhibitory currents changed slightly during 20 min of patch-clamp recording. Internal perfusion of the neurons with 1 microM okadaic acid, a phosphatase inhibitor, induced potentiation in both currents. The amplitude of GABA(A) and glycine currents recorded with 1 mM internal CaCl2 and 10 mM EGTA (10 nM free Ca2+) decayed by less than 30% of control. Increasing the CaCl2 concentration to 10 mM (34 microM free Ca2+) induced a transient potentiation of the GABA(A) current. A strong depression of current amplitude was found with longer times of dialysis. The glycine current, on the contrary, was unchanged by increasing the intracellular Ca2+ concentration. Activation of G proteins with internal FAl4- induced an inhibition of the GABA(A) current, but potentiated the amplitude of the strychnine-sensitive Cl- current. These results indicate that GABA(A) and glycine receptors are differentially regulated by activation of protein kinases, G proteins and Ca2+. This conclusion supports the existence of selectivity in the intracellular regulation of these two receptor types. | lld:pubmed |
| pubmed-article:9374187 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374187 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9374187 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374187 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9374187 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9374187 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9374187 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:9374187 | pubmed:author | pubmed-author:TapiaJ CJC | lld:pubmed |
| pubmed-article:9374187 | pubmed:author | pubmed-author:AguayoL GLG | lld:pubmed |
| pubmed-article:9374187 | pubmed:author | pubmed-author:EspinozaFF | lld:pubmed |
| pubmed-article:9374187 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9374187 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:9374187 | pubmed:volume | 769 | lld:pubmed |
| pubmed-article:9374187 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9374187 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9374187 | pubmed:pagination | 203-10 | lld:pubmed |
| pubmed-article:9374187 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9374187 | pubmed:meshHeading | pubmed-meshheading:9374187-... | lld:pubmed |
| pubmed-article:9374187 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9374187 | pubmed:articleTitle | Differential intracellular regulation of cortical GABA(A) and spinal glycine receptors in cultured neurons. | lld:pubmed |
| pubmed-article:9374187 | pubmed:affiliation | Department of Physiology, University of Concepcion, Chile. | lld:pubmed |
| pubmed-article:9374187 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9374187 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9374187 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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