| pubmed-article:9374036 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9374036 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:9374036 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:9374036 | lifeskim:mentions | umls-concept:C0007745 | lld:lifeskim |
| pubmed-article:9374036 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:9374036 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9374036 | pubmed:dateCreated | 1997-12-9 | lld:pubmed |
| pubmed-article:9374036 | pubmed:abstractText | The sphingomyelin pathway is a ubiquitous, evolutionarily conserved signaling system initiated by hydrolysis of the plasma membrane phospholipid sphingomyelin to generate ceramide. Ceramide acts as a second messenger in activating the apoptotic cascade. Diverse cytokine receptors and environmental stresses utilize ceramide to signal apoptosis. In several cell systems ceramide links to the stress-activated protein kinase (SAPK)/c-jun kinase (JNK) cascade to signal apoptosis. The engagement of the sphingomyelin pathway in signaling apoptosis is tightly regulated by anti-apoptotic control mechanisms, and the balance between pro- and anti-apoptotic systems determines the magnitude of the apoptotic response in vitro and in vivo. This review describes the known elements and molecular ordering of ceramide-mediated apoptosis and the anti-apoptotic mechanisms that regulate its expression. Understanding of pro- and anti-apoptotic signaling involved in ceramide-mediated apoptosis and the modes of their co-ordinated function may yield opportunities for pharmacological interventions with potential for clinical applications. | lld:pubmed |
| pubmed-article:9374036 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374036 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374036 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374036 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9374036 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374036 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9374036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374036 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9374036 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9374036 | pubmed:issn | 0007-1420 | lld:pubmed |
| pubmed-article:9374036 | pubmed:author | pubmed-author:FuksZZ | lld:pubmed |
| pubmed-article:9374036 | pubmed:author | pubmed-author:KolesnickR... | lld:pubmed |
| pubmed-article:9374036 | pubmed:author | pubmed-author:Haimovitz-Fri... | lld:pubmed |
| pubmed-article:9374036 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9374036 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:9374036 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9374036 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9374036 | pubmed:pagination | 539-53 | lld:pubmed |
| pubmed-article:9374036 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9374036 | pubmed:meshHeading | pubmed-meshheading:9374036-... | lld:pubmed |
| pubmed-article:9374036 | pubmed:meshHeading | pubmed-meshheading:9374036-... | lld:pubmed |
| pubmed-article:9374036 | pubmed:meshHeading | pubmed-meshheading:9374036-... | lld:pubmed |
| pubmed-article:9374036 | pubmed:meshHeading | pubmed-meshheading:9374036-... | lld:pubmed |
| pubmed-article:9374036 | pubmed:meshHeading | pubmed-meshheading:9374036-... | lld:pubmed |
| pubmed-article:9374036 | pubmed:meshHeading | pubmed-meshheading:9374036-... | lld:pubmed |
| pubmed-article:9374036 | pubmed:meshHeading | pubmed-meshheading:9374036-... | lld:pubmed |
| pubmed-article:9374036 | pubmed:meshHeading | pubmed-meshheading:9374036-... | lld:pubmed |
| pubmed-article:9374036 | pubmed:meshHeading | pubmed-meshheading:9374036-... | lld:pubmed |
| pubmed-article:9374036 | pubmed:meshHeading | pubmed-meshheading:9374036-... | lld:pubmed |
| pubmed-article:9374036 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9374036 | pubmed:articleTitle | Ceramide signaling in apoptosis. | lld:pubmed |
| pubmed-article:9374036 | pubmed:affiliation | Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, USA. | lld:pubmed |
| pubmed-article:9374036 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9374036 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9374036 | pubmed:publicationType | Review | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9374036 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9374036 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9374036 | lld:pubmed |
