| pubmed-article:9373634 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9373634 | lifeskim:mentions | umls-concept:C0024537 | lld:lifeskim |
| pubmed-article:9373634 | lifeskim:mentions | umls-concept:C0162643 | lld:lifeskim |
| pubmed-article:9373634 | lifeskim:mentions | umls-concept:C1335439 | lld:lifeskim |
| pubmed-article:9373634 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:9373634 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:9373634 | lifeskim:mentions | umls-concept:C0681842 | lld:lifeskim |
| pubmed-article:9373634 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:9373634 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:9373634 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9373634 | pubmed:dateCreated | 1997-12-9 | lld:pubmed |
| pubmed-article:9373634 | pubmed:abstractText | With the emergence of chloroquine-resistant Plasmodium vivax (CRPV), new tests to detect P. vivax and predict response to therapy would be useful for clinical and research applications. We performed a 'blinded' evaluation of a non-isotopic (colourimetric) polymerase chain reaction (PCR) based assay (Digene SHARP Signal System) compared with microscopy and PCR/radiometric probe hybridization of ribosomal ribonucleic acid genes (RPH) for the detection of P. vivax malaria in 182 febrile travellers. Compared with PCR/RPH as the reference standard, the colourimetric assay had a sensitivity of 100% and specificity of 98%. Using microscopy as the reference standard, 84 of 87 patients with P. vivax infection had a positive colourimetric assay. The 3 patients with a negative assay were subsequently shown to be infected with P. ovale as determined by PCR/RPH. In a subset of patients followed longitudinally, the colourimetric assay was positive in 5 of 13 patients 6 or more days after initiation of therapy. Of these 5 patients, 4 were subsequently demonstrated to be infected with CRPV as determined by treatment failure in vivo and/or chloroquine blood levels. A positive assay result 6 or more days after initiation of therapy was associated with subsequent treatment failure (P < 0.01). This non-isotopic assay is a sensitive, specific, and rapid method for the detection of P. vivax PCR products and may prove useful in predicting treatment failure. | lld:pubmed |
| pubmed-article:9373634 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9373634 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9373634 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9373634 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9373634 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9373634 | pubmed:issn | 0035-9203 | lld:pubmed |
| pubmed-article:9373634 | pubmed:author | pubmed-author:KainK CKC | lld:pubmed |
| pubmed-article:9373634 | pubmed:author | pubmed-author:HarringtonM... | lld:pubmed |
| pubmed-article:9373634 | pubmed:author | pubmed-author:HumadSS | lld:pubmed |
| pubmed-article:9373634 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9373634 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:9373634 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9373634 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9373634 | pubmed:pagination | 406-9 | lld:pubmed |
| pubmed-article:9373634 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9373634 | pubmed:meshHeading | pubmed-meshheading:9373634-... | lld:pubmed |
| pubmed-article:9373634 | pubmed:meshHeading | pubmed-meshheading:9373634-... | lld:pubmed |
| pubmed-article:9373634 | pubmed:meshHeading | pubmed-meshheading:9373634-... | lld:pubmed |
| pubmed-article:9373634 | pubmed:meshHeading | pubmed-meshheading:9373634-... | lld:pubmed |
| pubmed-article:9373634 | pubmed:meshHeading | pubmed-meshheading:9373634-... | lld:pubmed |
| pubmed-article:9373634 | pubmed:meshHeading | pubmed-meshheading:9373634-... | lld:pubmed |
| pubmed-article:9373634 | pubmed:meshHeading | pubmed-meshheading:9373634-... | lld:pubmed |
| pubmed-article:9373634 | pubmed:meshHeading | pubmed-meshheading:9373634-... | lld:pubmed |
| pubmed-article:9373634 | pubmed:meshHeading | pubmed-meshheading:9373634-... | lld:pubmed |
| pubmed-article:9373634 | pubmed:meshHeading | pubmed-meshheading:9373634-... | lld:pubmed |
| pubmed-article:9373634 | pubmed:meshHeading | pubmed-meshheading:9373634-... | lld:pubmed |
| pubmed-article:9373634 | pubmed:articleTitle | Evaluation of a non-isotopic polymerase chain reaction-based assay to detect and predict treatment failure of Plasmodium vivax malaria in travellers. | lld:pubmed |
| pubmed-article:9373634 | pubmed:affiliation | Department of Medicine, Toronto Hospital, Ontario, Canada. | lld:pubmed |
| pubmed-article:9373634 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9373634 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9373634 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9373634 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9373634 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9373634 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9373634 | lld:pubmed |
