| pubmed-article:9372961 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9372961 | lifeskim:mentions | umls-concept:C1442824 | lld:lifeskim |
| pubmed-article:9372961 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:9372961 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:9372961 | lifeskim:mentions | umls-concept:C0443299 | lld:lifeskim |
| pubmed-article:9372961 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:9372961 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:9372961 | lifeskim:mentions | umls-concept:C1518803 | lld:lifeskim |
| pubmed-article:9372961 | lifeskim:mentions | umls-concept:C0733688 | lld:lifeskim |
| pubmed-article:9372961 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:9372961 | pubmed:dateCreated | 1997-12-16 | lld:pubmed |
| pubmed-article:9372961 | pubmed:abstractText | OCA-B is a B-cell-specific coregulator of the broadly expressed POU domain transcription factor Oct-1. OCA-B associates with the Oct-1 POU domain, a bipartite DNA-binding structure containing a POU-specific (POU[S]) domain joined by a flexible linker to a POU homeodomain (POU[H]). Here, we show that OCA-B alters the activity of Oct-1 in two ways. It provides a transcriptional activation domain which, unlike Oct-1, activates an mRNA-type promoter effectively, and it stabilizes Oct-1 on the Oct-1-responsive octamer sequence ATGCAAAT. These properties of OCA-B parallel those displayed by the herpes simplex virus Oct-1 coregulator VP16. OCA-B, however, interacts with a different surface of the DNA-bound Oct-1 POU domain, interacting with both the POU(S) and POU(H) domains and the center of the ATGCAAAT octamer sequence. The OCA-B and VP16 interactions with the Oct-1 POU domain are sufficiently different to permit OCA-B and VP16 to bind the Oct-1 POU domain simultaneously. These results emphasize the structural versatility of the Oct-1 POU domain in its interaction with coregulators. | lld:pubmed |
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| pubmed-article:9372961 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9372961 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9372961 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9372961 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9372961 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9372961 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9372961 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:9372961 | pubmed:author | pubmed-author:BabaSS | lld:pubmed |
| pubmed-article:9372961 | pubmed:author | pubmed-author:HerrWW | lld:pubmed |
| pubmed-article:9372961 | pubmed:author | pubmed-author:ClearyM AMA | lld:pubmed |
| pubmed-article:9372961 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9372961 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9372961 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9372961 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9372961 | pubmed:pagination | 7295-305 | lld:pubmed |
| pubmed-article:9372961 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9372961 | pubmed:meshHeading | pubmed-meshheading:9372961-... | lld:pubmed |
| pubmed-article:9372961 | pubmed:meshHeading | pubmed-meshheading:9372961-... | lld:pubmed |
| pubmed-article:9372961 | pubmed:meshHeading | pubmed-meshheading:9372961-... | lld:pubmed |
