| pubmed-article:9371336 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9371336 | lifeskim:mentions | umls-concept:C0036766 | lld:lifeskim |
| pubmed-article:9371336 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:9371336 | lifeskim:mentions | umls-concept:C0597979 | lld:lifeskim |
| pubmed-article:9371336 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:9371336 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9371336 | pubmed:dateCreated | 1998-1-23 | lld:pubmed |
| pubmed-article:9371336 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:abstractText | A natural TEM variant beta-lactamase was isolated from an epidemic strain of Serratia marcescens. Nucleotide gene sequencing revealed multiple point mutations located in the 42-to-44 tripeptide and positions 145 to 146, 178, and 238. In addition, a glutamic acid 212 deletion was also found. The purified enzyme was studied from a kinetic point of view, revealing the highest catalytic efficiency (k[cat]/Km) values for ceftazidime and aztreonam compared with the TEM-1 prototype enzyme. The in vitro resistance correlated with kinetic parameters, and the enzyme also mediated resistance to some penicillins and an ampicillin-clavulanic acid combination. The mutational and kinetic changes are discussed in relation to the three-dimensional crystallographic structure of the wild-type TEM-1 enzyme. | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9371336 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9371336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9371336 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9371336 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9371336 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:9371336 | pubmed:author | pubmed-author:OratoreAA | lld:pubmed |
| pubmed-article:9371336 | pubmed:author | pubmed-author:AmicosanteGG | lld:pubmed |
| pubmed-article:9371336 | pubmed:author | pubmed-author:De SantisAA | lld:pubmed |
| pubmed-article:9371336 | pubmed:author | pubmed-author:FeliciAA | lld:pubmed |
| pubmed-article:9371336 | pubmed:author | pubmed-author:PaganoFF | lld:pubmed |
| pubmed-article:9371336 | pubmed:author | pubmed-author:KnoxJ RJR | lld:pubmed |
| pubmed-article:9371336 | pubmed:author | pubmed-author:FranceschiniN... | lld:pubmed |
| pubmed-article:9371336 | pubmed:author | pubmed-author:RossoliniG... | lld:pubmed |
| pubmed-article:9371336 | pubmed:author | pubmed-author:PerilliMM | lld:pubmed |
| pubmed-article:9371336 | pubmed:author | pubmed-author:LuzzaroFF | lld:pubmed |
| pubmed-article:9371336 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9371336 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:9371336 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9371336 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9371336 | pubmed:pagination | 2374-82 | lld:pubmed |
| pubmed-article:9371336 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9371336 | pubmed:meshHeading | pubmed-meshheading:9371336-... | lld:pubmed |
| pubmed-article:9371336 | pubmed:meshHeading | pubmed-meshheading:9371336-... | lld:pubmed |
| pubmed-article:9371336 | pubmed:meshHeading | pubmed-meshheading:9371336-... | lld:pubmed |
| pubmed-article:9371336 | pubmed:meshHeading | pubmed-meshheading:9371336-... | lld:pubmed |
| pubmed-article:9371336 | pubmed:meshHeading | pubmed-meshheading:9371336-... | lld:pubmed |
| pubmed-article:9371336 | pubmed:meshHeading | pubmed-meshheading:9371336-... | lld:pubmed |
| pubmed-article:9371336 | pubmed:meshHeading | pubmed-meshheading:9371336-... | lld:pubmed |
| pubmed-article:9371336 | pubmed:meshHeading | pubmed-meshheading:9371336-... | lld:pubmed |
| pubmed-article:9371336 | pubmed:meshHeading | pubmed-meshheading:9371336-... | lld:pubmed |
| pubmed-article:9371336 | pubmed:meshHeading | pubmed-meshheading:9371336-... | lld:pubmed |
| pubmed-article:9371336 | pubmed:meshHeading | pubmed-meshheading:9371336-... | lld:pubmed |
| pubmed-article:9371336 | pubmed:meshHeading | pubmed-meshheading:9371336-... | lld:pubmed |
| pubmed-article:9371336 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9371336 | pubmed:articleTitle | Characterization of a new TEM-derived beta-lactamase produced in a Serratia marcescens strain. | lld:pubmed |
| pubmed-article:9371336 | pubmed:affiliation | Dipartimento di Scienze e Tecnologie Biomediche, Cattedra di Chimica Biologica, Facoltà di Medicina e Chirurgia, Università degli Studi dell'Aquila, L'Aquila, Italy. | lld:pubmed |
| pubmed-article:9371336 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9371336 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9371336 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9371336 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9371336 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9371336 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9371336 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9371336 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9371336 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9371336 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9371336 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9371336 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9371336 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9371336 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9371336 | lld:pubmed |
