| pubmed-article:9364067 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9364067 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:9364067 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:9364067 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:9364067 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:9364067 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:9364067 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:9364067 | lifeskim:mentions | umls-concept:C0430297 | lld:lifeskim |
| pubmed-article:9364067 | lifeskim:mentions | umls-concept:C1710030 | lld:lifeskim |
| pubmed-article:9364067 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9364067 | lifeskim:mentions | umls-concept:C0392760 | lld:lifeskim |
| pubmed-article:9364067 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9364067 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:9364067 | pubmed:dateCreated | 1997-12-15 | lld:pubmed |
| pubmed-article:9364067 | pubmed:abstractText | The reeler mutation in mice produces an especially well characterized disorder, with systematically abnormal migration of cerebral cortical neurons. The reeler gene encodes a large protein, termed Reelin, that in the cortex is synthesized and secreted exclusively in the Cajal-Retzius neurons of the cortical marginal zone (D'Arcangelo et al., 1995). In reeler mutant mice, loss of Reelin protein is associated with a systematic loss of the normal, "inside-out" sequence of neurogenesis in the cortex: neurons are formed in the normal sequence but become localized in the cortex in a somewhat inverted, although relatively disorganized "outside-in" pattern. Here we show that the scrambler mutant mouse exhibits a loss of lamination in the cortex and hippocampus that is indistinguishable from that seen in the reeler mouse. We use BrdU birthdating studies to show that scrambler cortex shows a somewhat inverted "outside-in" sequence of birthdates for cortical neurons that is similar to that previously described in reeler cortex. Finally, we perform staining with the CR-50 monoclonal antibody (Ogawa et al., 1995), which recognizes the Reelin protein (D'Arcangelo et al., 1997). We show that Reelin immunoreactivity is present in the scrambler cortex in a normal pattern, suggesting that Reelin is synthesized and released normally. Our data suggest that scrambler is a mutation in the same gene pathway as the reeler gene (Relnrl) and is most likely downstream of Relnrl. | lld:pubmed |
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| pubmed-article:9364067 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9364067 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9364067 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9364067 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9364067 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9364067 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9364067 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9364067 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9364067 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9364067 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:9364067 | pubmed:author | pubmed-author:GonzálezJ LJL | lld:pubmed |
| pubmed-article:9364067 | pubmed:author | pubmed-author:SweetH OHO | lld:pubmed |
| pubmed-article:9364067 | pubmed:author | pubmed-author:DavissonM TMT | lld:pubmed |
| pubmed-article:9364067 | pubmed:author | pubmed-author:GoldowitzDD | lld:pubmed |
| pubmed-article:9364067 | pubmed:author | pubmed-author:WalshC ACA | lld:pubmed |
| pubmed-article:9364067 | pubmed:author | pubmed-author:RussoC JCJ | lld:pubmed |
| pubmed-article:9364067 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9364067 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9364067 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:9364067 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9364067 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9364067 | pubmed:pagination | 9204-11 | lld:pubmed |
| pubmed-article:9364067 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9364067 | pubmed:meshHeading | pubmed-meshheading:9364067-... | lld:pubmed |
| pubmed-article:9364067 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9364067 | pubmed:articleTitle | Birthdate and cell marker analysis of scrambler: a novel mutation affecting cortical development with a reeler-like phenotype. | lld:pubmed |
| pubmed-article:9364067 | pubmed:affiliation | Division of Neurogenetics, Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA. | lld:pubmed |
| pubmed-article:9364067 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9364067 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:9364067 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9364067 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9364067 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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